Carnosine Decreases PMA-Induced Oxidative Stress and Inflammation in Murine Macrophages.
antioxidants
carnosine
inflammation
macrophages
oxidative stress
superoxide
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
06 Aug 2019
06 Aug 2019
Historique:
received:
22
06
2019
revised:
23
07
2019
accepted:
31
07
2019
entrez:
9
8
2019
pubmed:
9
8
2019
medline:
9
8
2019
Statut:
epublish
Résumé
Carnosine is an endogenous dipeptide composed of β-alanine and L-histidine. This naturally occurring molecule is present at high concentrations in several mammalian excitable tissues such as muscles and brain, while it can be found at low concentrations in a few invertebrates. Carnosine has been shown to be involved in different cellular defense mechanisms including the inhibition of protein cross-linking, reactive oxygen and nitrogen species detoxification as well as the counteraction of inflammation. As a part of the immune response, macrophages are the primary cell type that is activated. These cells play a crucial role in many diseases associated with oxidative stress and inflammation, including atherosclerosis, diabetes, and neurodegenerative diseases. In the present study, carnosine was first tested for its ability to counteract oxidative stress. In our experimental model, represented by RAW 264.7 macrophages challenged with phorbol 12-myristate 13-acetate (PMA) and superoxide dismutase (SOD) inhibitors, carnosine was able to decrease the intracellular concentration of superoxide anions (O
Identifiants
pubmed: 31390749
pii: antiox8080281
doi: 10.3390/antiox8080281
pmc: PMC6720685
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : American Heart Association
ID : NFP0075515
Organisme : NIGMS NIH HHS
ID : P20 GM103638
Pays : United States
Organisme : National Science Foundation
ID : CHE-1411993
Organisme : Ministero della Salute
ID : RC: 2635256
Organisme : NIH HHS
ID : P20GM103638
Pays : United States
Références
Circulation. 2002 Mar 26;105(12):1429-35
pubmed: 11914250
Mol Neurobiol. 2016 Oct;53(8):5582-90
pubmed: 26476839
Arch Gerontol Geriatr. 2014 Sep-Oct;59(2):485-90
pubmed: 24880197
Nature. 1992 Oct 22;359(6397):693-9
pubmed: 1436033
Biol Rev Camb Philos Soc. 2017 Feb;92(1):369-377
pubmed: 26548761
Neuropharmacology. 2017 Jul 15;121:30-38
pubmed: 28431972
Prog Neurobiol. 2019 Apr;175:35-53
pubmed: 30593839
Cell Death Dis. 2018 Feb 14;9(2):245
pubmed: 29445138
Biochem Mol Biol Int. 1997 Sep;43(1):99-106
pubmed: 9315287
Immunology. 2015 Jun;145(2):213-24
pubmed: 25545227
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):560-5
pubmed: 25548165
J Biol Chem. 1959 Dec;234:3210-8
pubmed: 14404206
Mol Genet Metab. 2018 Nov;125(3):305-313
pubmed: 30146452
Biochim Biophys Acta. 1999 Nov 16;1472(3):651-7
pubmed: 10564779
ScientificWorldJournal. 2011;11:2391-402
pubmed: 22194670
Pharmacol Rep. 2013;65(6):1663-72
pubmed: 24553015
Antioxid Redox Signal. 2011 Sep 15;15(6):1583-606
pubmed: 21473702
J Biol Chem. 2010 Mar 26;285(13):9346-9356
pubmed: 20097752
Exp Diabetes Res. 2012;2012:703538
pubmed: 22110477
Hum Exp Toxicol. 2011 Dec;30(12):1979-85
pubmed: 21464095
J Immunol. 2006 Nov 1;177(9):6317-24
pubmed: 17056562
Biomed Res Int. 2013;2013:484613
pubmed: 24455696
Front Immunol. 2017 Feb 27;8:200
pubmed: 28289419
Redox Biol. 2015 Aug;5:398-408
pubmed: 26163808
Acta Pharmacol Sin. 2019 Jul;40(7):938-948
pubmed: 30560903
Brain Res Bull. 2016 Jun;124:76-84
pubmed: 27040711
Chem Cent J. 2013 Feb 25;7(1):38
pubmed: 23442334
Curr Med Chem. 2005;12(20):2293-315
pubmed: 16181134
Int Immunol. 2018 Oct 29;30(11):511-528
pubmed: 30165385
J Agric Food Chem. 2010 Nov 10;58(21):11510-6
pubmed: 20925384
Anal Chem. 2013 Nov 5;85(21):10188-95
pubmed: 24010877
Biochem Pharmacol. 1986 May 15;35(10):1762-4
pubmed: 3011015
Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15038-43
pubmed: 17015830
Biochem Biophys Res Commun. 2000 Nov 11;278(1):1-8
pubmed: 11071846
Biomolecules. 2015 Apr 15;5(2):472-84
pubmed: 25884116
Comp Biochem Physiol. 1970 Dec 1;37(3):413-9
pubmed: 4250488
Eur J Pharmacol. 2011 Sep 30;667(1-3):202-7
pubmed: 21693116
Annu Rev Immunol. 2009;27:451-83
pubmed: 19105661
Hum Reprod. 2018 Oct 1;33(10):1817-1828
pubmed: 30239786
J Food Drug Anal. 2017 Jan;25(1):111-118
pubmed: 28911528
J Cancer. 2014 Apr 24;5(5):382-9
pubmed: 24799956
ACS Chem Biol. 2009 Mar 20;4(3):161-77
pubmed: 19267456
Ann N Y Acad Sci. 1998 Nov 20;854:37-53
pubmed: 9928418
Mitochondrion. 2019 Jul;47:266-272
pubmed: 30664953
Immunol Res. 2012 Sep;53(1-3):11-24
pubmed: 22418728
Anal Bioanal Chem. 2017 Jul;409(19):4529-4538
pubmed: 28555342
Sci Rep. 2017 Mar 10;7:44492
pubmed: 28281693
PLoS One. 2015 Feb 06;10(2):e0116549
pubmed: 25658940
Anal Methods. 2017 Jan 21;9(3):402-408
pubmed: 29104617
Sci Rep. 2015 Jun 10;5:11252
pubmed: 26059637
Pharmacol Res. 2018 Apr;130:374-384
pubmed: 29438781
Int J Mol Sci. 2017 Sep 30;18(10):
pubmed: 28973964
Mol Cell Biochem. 2017 Jul;431(1-2):197-210
pubmed: 28290048
Pharmaceuticals (Basel). 2018 Oct 21;11(4):
pubmed: 30347874
J Biochem Mol Toxicol. 2017 Jul;31(7):
pubmed: 28266762
Age Ageing. 2000 May;29(3):207-10
pubmed: 10855900
Ann N Y Acad Sci. 2002 May;962:207-11
pubmed: 12076976
Anal Biochem. 2003 Nov 1;322(1):51-9
pubmed: 14705780
Biochim Biophys Acta. 2000 Oct 20;1498(1):19-31
pubmed: 11042347
Regul Pept. 2014 Jun-Aug;192-193:45-52
pubmed: 25195162
Neuroscience. 2016 Aug 25;330:326-34
pubmed: 27268280
J Neuroinflammation. 2005 Sep 12;2:20
pubmed: 16156895
Cardiovasc Res. 2002 Aug 1;55(2):239-49
pubmed: 12123763
Cells. 2019 Jan 17;8(1):
pubmed: 30658430
Diabetes. 2009 Nov;58(11):2574-82
pubmed: 19690061
Anal Bioanal Chem. 2015 Sep;407(23):7003-12
pubmed: 26159570
Int J Mol Sci. 2017 Apr 17;18(4):
pubmed: 28420166
Biosci Rep. 2010 Mar 12;30(4):233-41
pubmed: 19673702
Res Immunol. 1997 Sep;148(7):453-6
pubmed: 9498004
Physiol Rev. 2013 Oct;93(4):1803-45
pubmed: 24137022
Eur J Pharmacol. 2016 Sep 15;787:72-7
pubmed: 26845696
Front Aging Neurosci. 2015 Nov 27;7:219
pubmed: 26640437
Immunol Lett. 2018 Sep;201:38-44
pubmed: 30385329
Mol Microbiol. 2011 May;80(3):580-3
pubmed: 21375590
Curr Pharm Biotechnol. 2018;19(15):1196-1202
pubmed: 30636599
J Alzheimers Dis. 2013;33(4):983-97
pubmed: 23099816
Biokhimiia. 1992 Sep;57(9):1352-9
pubmed: 1467354
Pharmacol Rep. 2010 Jul-Aug;62(4):733-9
pubmed: 20885014
Mol Biotechnol. 2007 Sep;37(1):2-4
pubmed: 17914156
Analyst. 2014 Jul 7;139(13):3265-73
pubmed: 24728039
J Clin Biochem Nutr. 2015 Jan;56(1):1-7
pubmed: 25834301
Antioxidants (Basel). 2019 Apr 11;8(4):
pubmed: 30978904
Anal Methods. 2019 Jan 14;11(2):148-156
pubmed: 31579404
Nutrients. 2017 Oct 31;9(11):
pubmed: 29088099
Biochim Biophys Acta. 1959 Jan;31(1):47-55
pubmed: 13628602
Cell Physiol Biochem. 2015;37(2):816-24
pubmed: 26356271
Circulation. 1999 Jul 20;100(3):216-8
pubmed: 10411841
World Allergy Organ J. 2012 Jan;5(1):9-19
pubmed: 23268465