Serum matrix metalloproteinase-9 in children exposed to arsenic from playground dust at elementary schools in Hermosillo, Sonora, Mexico.
Arsenic
Children
Playground dust
Serum MMP-9
Journal
Environmental geochemistry and health
ISSN: 1573-2983
Titre abrégé: Environ Geochem Health
Pays: Netherlands
ID NLM: 8903118
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
24
01
2019
accepted:
24
07
2019
pubmed:
3
8
2019
medline:
14
5
2020
entrez:
3
8
2019
Statut:
ppublish
Résumé
Arsenic exposure in adults has been associated with increased serum matrix metalloproteinase-9 (MMP-9), a biomarker which is associated with chronic respiratory disease, lung inflammation, cardiovascular disease and cancer. The objective of this study was to evaluate the association between serum MMP-9 levels in children, urinary arsenic, arsenic chronic daily intake (CDI) and arsenic exposure from playground dust. This cross-sectional study examined 127 children from five elementary schools, in Hermosillo, Sonora, Mexico. Arsenic was analyzed in the dust using a portable X-ray fluorescence (XRF) analyzer. Total urinary arsenic was determined by inductively coupled plasma/optical emission spectrometry. Serum was analyzed for MMP-9 using ELISA. Arsenic levels in playground dust averaged 16.9 ± 4.6 mg/kg. Urinary arsenic averaged 34.9 ± 17.1 µg/L. Arsenic concentration in playground dust was positively associated with serum MMP-9 levels in crude analyses and after adjustment (P < 0.01), MMP-9 and CDI were positively associated only after adjustment (P < 0.01), and no association was found between MMP-9 and urinary arsenic. In conclusion, our study showed an association in children between serum MMP-9 levels and playground dust arsenic concentrations. Therefore, exposure to arsenic in dust where children spend significant time may manifest toxic effects.
Identifiants
pubmed: 31372863
doi: 10.1007/s10653-019-00384-6
pii: 10.1007/s10653-019-00384-6
pmc: PMC8845485
mid: NIHMS1776051
doi:
Substances chimiques
Dust
0
Environmental Biomarkers
0
Environmental Pollutants
0
MMP9 protein, human
EC 3.4.24.35
Matrix Metalloproteinase 9
EC 3.4.24.35
Arsenic
N712M78A8G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
499-511Subventions
Organisme : CONACYT
ID : INFR-2016-1-269884
Organisme : NIEHS NIH HHS
ID : P30 ES006694
Pays : United States
Organisme : ITSON/PROFAPI-2018-0072
ID : 0072
Organisme : CONACYT
ID : CB-167676
Organisme : CONACYT
ID : FONSALUD-S0008-2014-1-233976
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