Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [
Ageing
BMI
PET
Sex difference
TSPO
[11C]PBR28
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
01
03
2019
accepted:
14
06
2019
pubmed:
1
8
2019
medline:
21
10
2020
entrez:
1
8
2019
Statut:
ppublish
Résumé
The purpose of this study was to investigate the effects of ageing, sex and body mass index (BMI) on translocator protein (TSPO) availability in healthy subjects using positron emission tomography (PET) and the radioligand [ [ There were significant positive correlations between age and V These findings provide evidence that individual biological properties may contribute significantly to the high variation shown in TSPO binding estimates, and suggest that age, BMI and sex can be confounding factors in clinical studies.
Identifiants
pubmed: 31363804
doi: 10.1007/s00259-019-04403-7
pii: 10.1007/s00259-019-04403-7
pmc: PMC6717599
doi:
Substances chimiques
(methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine
0
Pyrimidines
0
Receptors, GABA
0
TSPO protein, human
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2329-2338Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
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