Venoms and Isolated Toxins from Snakes of Medical Impact in the Northeast Argentina: State of the Art. Potential Pharmacological Applications.
Bothrops alternatus
Bothrops diporus
Crotalus durisus terrificus
Crotoxin
Metalloproteinases
Phospholipases A2
Serine/thrombin-like proteinases
Serinoproteases
Snake venom.
Journal
Current topics in medicinal chemistry
ISSN: 1873-4294
Titre abrégé: Curr Top Med Chem
Pays: United Arab Emirates
ID NLM: 101119673
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
03
2019
revised:
05
06
2019
accepted:
01
07
2019
pubmed:
28
7
2019
medline:
24
12
2019
entrez:
27
7
2019
Statut:
ppublish
Résumé
Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore, constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.
Identifiants
pubmed: 31345151
pii: CTMC-EPUB-99944
doi: 10.2174/1568026619666190725094851
doi:
Substances chimiques
Snake Venoms
0
Toxins, Biological
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1962-1980Informations de copyright
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