Effect of QUiPP prediction algorithm on treatment decisions in women with a previous preterm birth: a prospective cohort study.
Adult
Algorithms
Biomarkers
/ analysis
Cervical Length Measurement
Clinical Decision-Making
Female
Fetal Membranes, Premature Rupture
/ epidemiology
Fibronectins
/ analysis
Humans
Infant, Newborn
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, Second
/ physiology
Premature Birth
/ epidemiology
Prospective Studies
Risk Assessment
Risk Factors
United Kingdom
/ epidemiology
Cervical length
QUiPP
preterm birth prevention treatment
quantitative fetal fibronectin
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
accepted:
16
07
2019
pubmed:
25
7
2019
medline:
19
11
2019
entrez:
25
7
2019
Statut:
ppublish
Résumé
The QUiPP algorithm combines cervical length, quantitative fetal fibronectin (qfFN) and medical history to quantify risk of preterm birth. We assessed the utility of QUiPP to inform preterm birth prevention treatment decisions. A prospective cohort study with a subsequent impact assessment using the QUiPP risk of birth before 34 weeks' gestation. A UK tertiary referral hospital. In all, 119 women with previous spontaneous preterm birth (sPTB) or preterm premature rupture of membranes (PPROM) before 34 weeks' gestation. Cervical length and qfFN were measured at 19 Predictive statistics of QUiPP algorithm using 10% risk of sPTB before 34 Fifteen of 119 women (13%) had PPROM or sPTB before 34 weeks. Of these, 53% (8/15) had QUiPP risk of sPTB before 34 Use of the QUiPP algorithm in this population may lead to substantial increase in interventions without evidence that currently available treatment options are beneficial for this particular group. Independent study finds that the QUiPP algorithm could lead to substantial increases in treatment without evidence of benefit.
Identifiants
pubmed: 31339631
doi: 10.1111/1471-0528.15886
doi:
Substances chimiques
Biomarkers
0
Fibronectins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1569-1575Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2019 Royal College of Obstetricians and Gynaecologists.
Références
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