Synthesis and evaluation of cytotoxic and Na
Antineoplastic Agents, Phytogenic
/ chemical synthesis
Cardenolides
/ chemical synthesis
Cell Line
Cell Proliferation
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors
/ chemical synthesis
Humans
Molecular Conformation
Nerium
/ chemistry
Sodium-Potassium-Exchanging ATPase
/ antagonists & inhibitors
Structure-Activity Relationship
ATP-ase inhibition
Cardenolides
Cytotoxicity
Furan transformation
Partial synthesis
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
15 Oct 2019
15 Oct 2019
Historique:
received:
31
05
2019
revised:
08
07
2019
accepted:
08
07
2019
pubmed:
22
7
2019
medline:
24
12
2019
entrez:
21
7
2019
Statut:
ppublish
Résumé
Oleandrin, the major biologically active constituent of shrub Nerium oleander preparations of which have been used in traditional Mediterranean and Asian medicine, attracts a great deal of attention due to its pronounced anticancer activity. The synthesis of oleandrigenin model, 16β-hydroxy-3β-methoxy-5α-card-20(22)-enolide 16-acetate, from androstenolone acetate through 17β-(3-furyl)-intermediates has been developed. Several related 17β-(butenolidyl)- and 17β-(furyl)-androstane derivatives were synthesized and tested for in vitro cytotoxic and Na
Identifiants
pubmed: 31325787
pii: S0223-5234(19)30647-6
doi: 10.1016/j.ejmech.2019.07.028
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Cardenolides
0
Enzyme Inhibitors
0
oleandrigenin
465-15-6
Sodium-Potassium-Exchanging ATPase
EC 7.2.2.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
417-429Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.