Risk factors for cytomegalovirus infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis.
Aged
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
/ diagnosis
Antibodies, Antineutrophil Cytoplasmic
/ blood
Body Mass Index
C-Reactive Protein
/ metabolism
Cytomegalovirus
/ immunology
Cytomegalovirus Infections
/ diagnosis
Female
Granulomatosis with Polyangiitis
/ diagnosis
Humans
Immunosuppressive Agents
/ administration & dosage
Japan
Logistic Models
Male
Methylprednisolone
/ administration & dosage
Middle Aged
Opportunistic Infections
/ diagnosis
Remission Induction
Retrospective Studies
Risk Factors
Severity of Illness Index
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
07
2018
accepted:
07
06
2019
entrez:
11
7
2019
pubmed:
11
7
2019
medline:
23
2
2020
Statut:
epublish
Résumé
Cytomegalovirus (CMV) infection under immunosuppression sometimes causes death. This study aimed to elucidate risk factors for CMV infection in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Patients with AAV who underwent remission induction treatment at Okayama University Hospital between 2006 and 2016 were retrospectively analyzed. The primary outcome was the development of CMV infection within 3 months. Of the 111 patients, 13 (11.7%) patients developed CMV infection. Patients with CMV infection were older (p = 0.030) and had a higher body mass index (p = 0.029) in comparison to those without CMV infection. A higher proportion had a severe form (p = 0.001) and granulomatosis with polyangiitis (GPA) (p = 0.001), as well as a higher Birmingham Vasculitis Activity Score (p = 0.018) and C-reactive protein (p = 0.018) levels at baseline. Using logistic regression analysis, severe form and GPA were independent risk factors (odds ratio [OR] = 9.68, 95% confidence interval [CI] = 1.92-60.23, and OR = 7.46, 95% CI = 1.46-47.60, respectively). In addition, patients with CMV infection were more likely than those without infection to be glucocorticoid-related diabetes mellitus (p = 0.025). Our study highlights disease severity and subgroups of AAV as risk factors for CMV infection.
Identifiants
pubmed: 31291263
doi: 10.1371/journal.pone.0218705
pii: PONE-D-18-20504
pmc: PMC6619987
doi:
Substances chimiques
Antibodies, Antineutrophil Cytoplasmic
0
Immunosuppressive Agents
0
C-Reactive Protein
9007-41-4
Methylprednisolone
X4W7ZR7023
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0218705Déclaration de conflit d'intérêts
The authors declare the following interests: JW received speaking honoraria from Astellas, Boehringer Ingelheim, Daiichi Novartis, Sankyo, and Tanabe Mitsubishi, and grant support from Astellas, Bayer, Baxter, Chugai, Daiichi Sankyo, Kissei, Kyowa Hakko Kirin, MSD, Novartis, Novo Nordisk, Ono, Otsuka, Pfizer, Teijin, Torii, and Takeda. KS has received lecture fees from Chugai. All other authors declare that they have no competing interests. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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