Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging.
Adolescent
Adult
Aging
/ metabolism
Aspartic Acid
/ analogs & derivatives
Choline
/ metabolism
Creatine
/ metabolism
Female
Glutamic Acid
/ metabolism
Glutamine
/ metabolism
Hippocampus
/ diagnostic imaging
Humans
Inositol
/ metabolism
Male
Middle Aged
Parahippocampal Gyrus
/ diagnostic imaging
Proton Magnetic Resonance Spectroscopy
/ methods
Protons
Young Adult
N-acetyl-aspartate
T1-weighting
aging
hippocampus
magnetic resonance spectroscopy
Journal
Journal of neuroimaging : official journal of the American Society of Neuroimaging
ISSN: 1552-6569
Titre abrégé: J Neuroimaging
Pays: United States
ID NLM: 9102705
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
10
04
2019
revised:
11
06
2019
accepted:
14
06
2019
pubmed:
6
7
2019
medline:
20
6
2020
entrez:
6
7
2019
Statut:
ppublish
Résumé
Previous magnetic resonance spectroscopy (MRS) studies have concluded that hippocampal and parahippocampal metabolite concentrations remain stable during healthy adult aging. However, these studies used short repetition times (TR ≤ 2 seconds), which lead to incomplete longitudinal magnetization recovery, and thus, heavily T Left hippocampal MR spectra were collected from 38 healthy volunteers at 3T. Absolute metabolite concentrations were determined for total N-acetyl-aspartate (tNAA), total creatine (tCr), total choline (tCho), glutamate and glutamine (Glx), and myoinositol (mI). Individual partial correlations between each metabolite with age were assessed using demographic information and voxel compartmentation as confounders. Hippocampal tNAA, tCr, tCho, and mI all increased with age (NAA: R We observed increases in hippocampal/parahippocampal metabolite concentrations with age, a finding that is in contrast to previous literature. Our findings illustrate the importance of using a sufficiently long TR in MRS to avoid T
Sections du résumé
BACKGROUND AND PURPOSE
Previous magnetic resonance spectroscopy (MRS) studies have concluded that hippocampal and parahippocampal metabolite concentrations remain stable during healthy adult aging. However, these studies used short repetition times (TR ≤ 2 seconds), which lead to incomplete longitudinal magnetization recovery, and thus, heavily T
METHODS
Left hippocampal MR spectra were collected from 38 healthy volunteers at 3T. Absolute metabolite concentrations were determined for total N-acetyl-aspartate (tNAA), total creatine (tCr), total choline (tCho), glutamate and glutamine (Glx), and myoinositol (mI). Individual partial correlations between each metabolite with age were assessed using demographic information and voxel compartmentation as confounders.
RESULTS
Hippocampal tNAA, tCr, tCho, and mI all increased with age (NAA: R
CONCLUSIONS
We observed increases in hippocampal/parahippocampal metabolite concentrations with age, a finding that is in contrast to previous literature. Our findings illustrate the importance of using a sufficiently long TR in MRS to avoid T
Substances chimiques
Protons
0
Glutamine
0RH81L854J
Aspartic Acid
30KYC7MIAI
Glutamic Acid
3KX376GY7L
Inositol
4L6452S749
Creatine
MU72812GK0
Choline
N91BDP6H0X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
592-597Subventions
Organisme : Michael Smith Foundation for Health Research
Pays : International
Organisme : Natural Sciences and Engineering Research Council of Canada
Pays : International
Informations de copyright
© 2019 by the American Society of Neuroimaging.
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