Anti-inflammatory Effect and Cellular Uptake Mechanism of Peptides from Common Bean (
Anti-Inflammatory Agents
/ metabolism
Biological Transport
Caco-2 Cells
Coculture Techniques
Endothelial Cells
/ metabolism
Epithelial Cells
/ metabolism
Humans
Intestinal Mucosa
/ metabolism
Intestines
/ cytology
NF-kappa B
/ genetics
Peptide Transporter 1
/ genetics
Peptides
/ chemistry
Phaseolus
/ chemistry
Plant Extracts
/ chemistry
Yogurt
/ analysis
anti-inflammation
cell uptake
co-culture
common beans
peptides
Journal
Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755
Informations de publication
Date de publication:
31 Jul 2019
31 Jul 2019
Historique:
pubmed:
5
7
2019
medline:
14
8
2019
entrez:
5
7
2019
Statut:
ppublish
Résumé
Naturally occurring dietary peptides derived from gastrointestinal digestates of common bean milk and yogurt were studied for their bioaccessibility, bioavailability, and anti-inflammatory activity in both Caco-2 mono- and Caco-2/EA.hy926 co-culture cell models. Anti-inflammatory activities of these peptide extracts were found to be strongly associated with cellular uptake by the intestinal epithelial cells. Mechanisms underlying the cellular uptake were studied by examining the role of peptide transporter 1 and calcium sensing reporter. Three peptides, including γ-glutamyl-
Identifiants
pubmed: 31271280
doi: 10.1021/acs.jafc.9b03079
doi:
Substances chimiques
Anti-Inflammatory Agents
0
NF-kappa B
0
Peptide Transporter 1
0
Peptides
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM