Monitoring Radiotherapeutic Response in Prostate Cancer Patients Using High Throughput FTIR Spectroscopy of Liquid Biopsies.
Fourier transform infrared spectroscopy
blood plasma
high throughput
prostate cancer
radiotherapy
toxicity
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
02 Jul 2019
02 Jul 2019
Historique:
received:
31
05
2019
revised:
26
06
2019
accepted:
28
06
2019
entrez:
5
7
2019
pubmed:
5
7
2019
medline:
5
7
2019
Statut:
epublish
Résumé
Radiation therapy (RT) is used to treat approximately 50% of all cancer patients. However, RT causes a wide range of adverse late effects that can affect a patient's quality of life. There are currently no predictive assays in clinical use to identify patients at risk of normal tissue radiation toxicity. This study aimed to investigate the potential of Fourier transform infrared (FTIR) spectroscopy for monitoring radiotherapeutic response. Blood plasma was acquired from 53 prostate cancer patients at five different time points: prior to treatment, after hormone treatment, at the end of radiotherapy, two months post radiotherapy and eight months post radiotherapy. FTIR spectra were recorded from plasma samples at all time points and the data was analysed using MATLAB software. Discrimination was observed between spectra recorded at baseline versus follow up time points, as well as between spectra from patients showing minimal and severe acute and late toxicity using principal component analysis. A partial least squares discriminant analysis model achieved sensitivity and specificity rates ranging from 80% to 99%. This technology may have potential to monitor radiotherapeutic response in prostate cancer patients using non-invasive blood plasma samples and could lead to individualised patient radiotherapy.
Identifiants
pubmed: 31269684
pii: cancers11070925
doi: 10.3390/cancers11070925
pmc: PMC6679106
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Irish Research Council
ID : GOIPG/2016/1538
Organisme : Science Foundation Ireland
ID : 11/RFP.1/BMT/3317
Pays : Ireland
Organisme : EU FP7 Network of Excellence DoReMi
ID : 249689
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