Novel shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine-associated receptor.
TAAR
arrector pili
hair shedding
piloerection
trace amine
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
15
04
2019
accepted:
04
06
2019
pubmed:
3
7
2019
medline:
5
6
2020
entrez:
3
7
2019
Statut:
ppublish
Résumé
Approximately 40% of women experience excessive hair shedding when washing their hair. Previously, we have demonstrated that a topically applied α1 adrenergic receptor agonist can be used to contract the arrector pili muscle of the follicular unit (ie, produce "goose bumps"), increasing the force required to pluck hair by as much as 400%. Subsequently, we reported a topical cosmetic solution containing an α1 adrenergic receptor agonist that reduced hair shedding during brushing by a maximum of 77%. In this communication, we explore a novel mechanism to contract the arrector pili muscle. Trace amine-associated receptors (TAAR) have been shown to regulate smooth muscle tone in blood vessels, but have not been reported to be present in the skin. Here, we report on the anti-shedding efficacy of a shampoo containing a selective TAAR agonist, tyramine hydrochloride. A single-blinded crossover study was designed to test the efficacy of the novel shampoo versus placebo in reducing hairs lost during brushing. In this study, the novel TAAR shampoo reduced hair shedding during brushing by 31% in a cohort of 24 women with a maximum reduction of 77%. A shampoo formulated with a selective TAAR agonist was demonstrated to contract the arrector pili muscle and reduce hair shedding subsequent to washing.
Sections du résumé
BACKGROUND
BACKGROUND
Approximately 40% of women experience excessive hair shedding when washing their hair. Previously, we have demonstrated that a topically applied α1 adrenergic receptor agonist can be used to contract the arrector pili muscle of the follicular unit (ie, produce "goose bumps"), increasing the force required to pluck hair by as much as 400%. Subsequently, we reported a topical cosmetic solution containing an α1 adrenergic receptor agonist that reduced hair shedding during brushing by a maximum of 77%.
AIMS
OBJECTIVE
In this communication, we explore a novel mechanism to contract the arrector pili muscle. Trace amine-associated receptors (TAAR) have been shown to regulate smooth muscle tone in blood vessels, but have not been reported to be present in the skin. Here, we report on the anti-shedding efficacy of a shampoo containing a selective TAAR agonist, tyramine hydrochloride.
METHODS
METHODS
A single-blinded crossover study was designed to test the efficacy of the novel shampoo versus placebo in reducing hairs lost during brushing.
RESULTS
RESULTS
In this study, the novel TAAR shampoo reduced hair shedding during brushing by 31% in a cohort of 24 women with a maximum reduction of 77%.
CONCLUSIONS
CONCLUSIONS
A shampoo formulated with a selective TAAR agonist was demonstrated to contract the arrector pili muscle and reduce hair shedding subsequent to washing.
Substances chimiques
Hair Preparations
0
Receptors, G-Protein-Coupled
0
Tyramine
X8ZC7V0OX3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2037-2039Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
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Sinclair R. Hair shedding in women: how much is too much? Br J Dermatol. 2015;173(3):846-848.
Kovacevic M, Goren A, Shapiro J, et al. Prevalence of hair shedding among women. Dermatol Ther. 2017;30(1):e12415.
Malkud S. Telogen effluvium: a review. J Clin Diagn Res. 2015;9:WE01-WE03.
Siepmann T, Gibbons CH, Illigens BM, Lafo JA, Brown CM, Freeman R. Quantitative pilomotor axon reflex test: a novel test of pilomotor function. Arch Neurol. 2012;69(11):1488-1492.
Goren A, Shapiro J, Sinclair R, Kovacevic M, McCoy J. α1-AR agonist induced piloerection protects against the development of traction alopecia. Dermatol Ther. 2016;29:160-163.
McCoy J, Goren A, Kovacevic M, et al. Styling without shedding: novel topical formula reduces hair shedding by contracting the arrector pili muscle. Dermatol Ther. 2017;e12575.
Broadley KJ. The vascular effects of trace amines and amphetamines. Pharmacol Ther. 2010;125:363-375.
Broadley KJ, Fehler M, Ford WR, Kidd EJ. Functional evaluation of the receptors mediating vasoconstriction of rat aorta by trace amines and amphetamines. Eur J Pharmacol. 2013;715:370-380.