Markers of Collagen Formation and Degradation Reflect Renal Function and Predict Adverse Outcomes in Patients With Type 1 Diabetes.
Aged
Biomarkers
/ blood
Collagen Type III
/ blood
Collagen Type VI
/ blood
Diabetes Mellitus, Type 1
/ blood
Diabetic Cardiomyopathies
/ etiology
Diabetic Nephropathies
/ etiology
Female
Glomerular Filtration Rate
Heart Failure
/ etiology
Humans
Kidney
/ physiopathology
Kidney Failure, Chronic
/ etiology
Male
Middle Aged
Procollagen
/ blood
Prognosis
Proportional Hazards Models
Risk Factors
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
19
12
2018
accepted:
13
06
2019
pubmed:
3
7
2019
medline:
19
5
2020
entrez:
3
7
2019
Statut:
ppublish
Résumé
Patients with type 1 diabetes (T1D) have a higher risk of developing chronic kidney disease, cardiovascular events (CVEs), and mortality than the general population. We hypothesized that two previously published biomarkers, namely PRO-C6, a biomarker of collagen type VI formation, and C3M, a biomarker of collagen type III degradation, may be associated with impaired renal function and have prognostic value for adverse renal, CVE, and mortality in patients with T1D. PRO-C6 and C3M in serum (sPRO-C6, sC3M) and urine (uPRO-C6, uC3M) were measured by ELISA in 663 patients with T1D ranging from normoalbuminuric to macroalbuminuric. Association of the biomarkers with mortality, CVEs, heart failure, decline in estimated glomerular filtration rate (eGFR) ≥30%, and end-stage renal disease (ESRD) were tested in Cox proportional hazards models after log High levels of sPRO-C6 were independently associated with a higher risk of all-cause mortality (HR 2.26 [95% CI 1.31-3.87], In patients with T1D, higher sPRO-C6 was an independent predictor of both decline in eGFR and development of ESRD and of all-cause mortality. Higher uPRO-C6 was also associated with a lower risk of decline in eGFR.
Identifiants
pubmed: 31262950
pii: dc18-2599
doi: 10.2337/dc18-2599
doi:
Substances chimiques
Biomarkers
0
Collagen Type III
0
Collagen Type VI
0
Procollagen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1760-1768Informations de copyright
© 2019 by the American Diabetes Association.