Holocaust history is not reflected in telomere homeostasis in survivors and their offspring.
Adaptation, Psychological
/ physiology
Adolescent
Adult
Adult Children
Adult Survivors of Child Adverse Events
Age Factors
Aged
Aged, 80 and over
Aging
/ physiology
Female
Holocaust
Humans
Male
Middle Aged
Real-Time Polymerase Chain Reaction
Stress Disorders, Post-Traumatic
/ metabolism
Stress, Psychological
/ metabolism
Survivors
Telomere Homeostasis
/ physiology
Telomere Shortening
/ physiology
Young Adult
Holocaust
Quantitative PCR
Stress
Telomere
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
07
02
2019
revised:
20
06
2019
accepted:
24
06
2019
pubmed:
1
7
2019
medline:
15
9
2020
entrez:
1
7
2019
Statut:
ppublish
Résumé
Telomeres, nucleoprotein structures at the ends of eukaryotic chromosomes, are crucial for the maintenance of genome integrity. While the lengths of telomeres at birth are determined genetically, many factors including environmental and living conditions affect the telomere lengths during a lifespan. In this context, extreme and long-term stress has been shown to negatively impact telomeres and their protective function, with even offspring being influenced by the stress experienced by parents. Using quantitative PCR, the relative lengths of telomeres of survivors of the Holocaust during World War II and two generations of their offspring were analyzed. These data were related to those of control groups, persons of comparable age without a strong life stress experience. In contrast to previous studies of other stress-exposed groups, the relative lengths of telomeres were comparable in groups of persons exposed to Holocaust-related stress and their progenies, and in control groups. Interestingly, shorter telomeres of Holocaust survivors of the age under 12 in the year 1945 compared to Holocaust survivors of the age above 12 were detected. Our results are discussed with respect to certain exceptionality of persons having been able to cope with an extreme stress more than 70 years ago and living to a very old age.
Identifiants
pubmed: 31255955
pii: S0022-3956(19)30161-X
doi: 10.1016/j.jpsychires.2019.06.018
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7-14Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.