Insights into pediatric rhabdomyosarcoma research: Challenges and goals.
cancer biology
early-phase clinical trials
genomics
rhabdomyosarcoma
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
07
03
2019
revised:
06
05
2019
accepted:
10
05
2019
pubmed:
22
6
2019
medline:
6
2
2020
entrez:
22
6
2019
Statut:
ppublish
Résumé
Overall survival rates for pediatric patients with high-risk or relapsed rhabdomyosarcoma (RMS) have not improved significantly since the 1980s. Recent studies have identified a number of targetable vulnerabilities in RMS, but these discoveries have infrequently translated into clinical trials. We propose streamlining the process by which agents are selected for clinical evaluation in RMS. We believe that strong consideration should be given to the development of combination therapies that add biologically targeted agents to conventional cytotoxic drugs. One example of this type of combination is the addition of the WEE1 inhibitor AZD1775 to the conventional cytotoxic chemotherapeutics, vincristine and irinotecan.
Identifiants
pubmed: 31222885
doi: 10.1002/pbc.27869
pmc: PMC6707829
mid: NIHMS1032428
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e27869Subventions
Organisme : NCI NIH HHS
ID : R01 CA251436
Pays : United States
Organisme : NIH HHS
ID : R24 OD016761
Pays : United States
Organisme : NIH HHS
ID : R24OD016761
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154923
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215118
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA216344
Pays : United States
Organisme : NIH HHS
ID : R01CA154923
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIH HHS
ID : R01CA215118
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA193339
Pays : United States
Organisme : NIH HHS
ID : R01CA226926
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA226926
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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