Microstructural characterization of annulus fibrosus by ultrasonography: a feasibility study with an in vivo and in vitro approach.
Geometry
Intervertebral disc
Lamellae
MRI
Microscopy
Journal
Biomechanics and modeling in mechanobiology
ISSN: 1617-7940
Titre abrégé: Biomech Model Mechanobiol
Pays: Germany
ID NLM: 101135325
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
05
03
2019
accepted:
12
06
2019
pubmed:
22
6
2019
medline:
20
3
2020
entrez:
22
6
2019
Statut:
ppublish
Résumé
The main function of the intervertebral disc is biomechanical function, since it must resist repetitive high loadings, while giving the spine its flexibility and protecting the spinal cord from over-straining. It partially owes its mechanical characteristics to the lamellar architecture of its outer layer, the annulus fibrosus. Today, no non-invasive means exist to characterize annulus lamellar structure in vivo. The aim of this work was to test the feasibility of imaging annulus fibrosus microstructure in vivo with ultrasonography. Twenty-nine healthy adolescents were included. Ultrasonographies of L3-L4 disc were acquired with a frontal approach. Annulus fibrosus was segmented in the images to measure the thickness of the lamellae. To validate lamellar appearance in ultrasonographies, multimodality images of two cow tail discs were compared: ultrasonography, magnetic resonance and optical microscopy. In vivo average lamellar thickness was 229.7 ± 91.5 μm, and it correlated with patient body mass index and age. Lamellar appearance in the three imaging modalities in vitro was consistent. Lamellar measurement uncertainty was 7%, with good agreement between two operators. Feasibility of ultrasonography for the analysis of lumbar annulus fibrosus structure was confirmed. Further work should aim at validating measurement reliability, and to assess the relevance of the method to characterize annulus alterations, for instance in disc degeneration or scoliosis.
Identifiants
pubmed: 31222527
doi: 10.1007/s10237-019-01189-3
pii: 10.1007/s10237-019-01189-3
pmc: PMC6825023
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1979-1986Subventions
Organisme : BiomecAM chair program
ID : -
Organisme : DHU MAMUTH
ID : -
Organisme : Société Française de Chirurgie Orthopédique et Traumatologie
ID : -
Organisme : Devon Arthritis and Allied Reasearch Fund
ID : -
Organisme : Henry Smith Charity
ID : -
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