Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium.

Adult Alanine Transaminase / genetics Aspartate Aminotransferases / genetics Female Genetic Loci Genome-Wide Association Study Humans Linear Models Lipase / genetics Liver / enzymology Male Membrane Proteins / genetics Mexican Americans / genetics Middle Aged Non-alcoholic Fatty Liver Disease / ethnology Polymorphism, Single Nucleotide gamma-Glutamyltransferase / genetics

Journal

Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860

Informations de publication

Date de publication:
08 2019
Historique:
received: 09 04 2019
accepted: 18 04 2019
pubmed: 21 6 2019
medline: 25 4 2020
entrez: 21 6 2019
Statut: ppublish

Résumé

Populations of Mexican American ancestry are at an increased risk for nonalcoholic fatty liver disease. The objective of this study was to determine whether loci in known and novel genes were associated with variation in aspartate aminotransferase (AST) (n = 3,644), alanine aminotransferase (ALT) (n = 3,595), and gamma-glutamyl transferase (GGT) (n = 1,577) levels by conducting the first genome-wide association study (GWAS) of liver enzymes, which commonly measure liver function, in individuals of Mexican American ancestry. Levels of AST, ALT, and GGT were determined by enzymatic colorimetric assays. A multi-cohort GWAS of individuals of Mexican American ancestry was performed. Single-nucleotide polymorphisms (SNP) were tested for association with liver outcomes by multivariable linear regression using an additive genetic model. Association analyses were conducted separately in each cohort, followed by a nonparametric meta-analysis. In the PNPLA3 gene, rs4823173 (P = 3.44 × 10 PNPLA3, a locus previously identified with ALT, AST, and nonalcoholic fatty liver disease in European and Japanese GWAS, is also associated with liver enzymes in populations of Mexican American ancestry.

Identifiants

DOI: 10.1002/oby.22527 PMID: 31219225 PMC: PMC6656610
pubmed: 31219225
doi: 10.1002/oby.22527
pmc: PMC6656610
mid: NIHMS1528348
doi:

Substances chimiques

Membrane Proteins 0
gamma-Glutamyltransferase EC 2.3.2.2
Aspartate Aminotransferases EC 2.6.1.1
Alanine Transaminase EC 2.6.1.2
Lipase EC 3.1.1.3
adiponutrin, human EC 3.1.1.3

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1331-1337

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK085175
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL067974
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK061628
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL088457
Pays : United States
Organisme : NIDDK NIH HHS
ID : HL-047889
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL060944
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL047902
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL061019
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL055798
Pays : United States
Organisme : NIDDK NIH HHS
ID : HL-047887
Pays : United States
Organisme : NIDDK NIH HHS
ID : HL-047890
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL047892
Pays : United States

Informations de copyright

© 2019 The Obesity Society.

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Auteurs

Kendra A Young (KA)

Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA.
ORCID: 0000-0002-8664-7635

Nicholette D Palmer (ND)

Department of Biochemistry, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.

Tasha E Fingerlin (TE)

Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA.
Center for Genes, Environment, and Health, National Jewish Health, Denver, Colorado, USA.

Carl D Langefeld (CD)

Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.

Jill M Norris (JM)

Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA.

Nan Wang (N)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Anny H Xiang (AH)

Research and Evaluation Branch, Kaiser Permanente of Southern California, Pasadena, California, USA.
ORCID: 0000-0003-2786-1268

Xiuqing Guo (X)

Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.

Adrienne H Williams (AH)

Department of Biostatistical Sciences, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.

Yii-Der I Chen (YI)

Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.
Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.

Kent D Taylor (KD)

Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.
Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.

Jerome I Rotter (JI)

Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.
Department of Pediatrics, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, California, USA.

Leslie J Raffel (LJ)

Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Mark O Goodarzi (MO)

Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Richard M Watanabe (RM)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Lynne E Wagenknecht (LE)

Division of Public Health Sciences, School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA.

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Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Alanine transaminase › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Aspartate aminotransferases › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles linéaires › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Triacylglycerol lipase › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Système digestif › Foie › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Personnes › Nord-Américains › Groupes de population aux États-Unis › Hispanique ou Latino › Américain origine mexicaine › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genome-Wide Association Study Identifies Loci...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Aminoacyltransferases › gamma-Glutamyltransferase › Genome-Wide Association Study Identifies Loci...