HIV infection among men who have sex with men in Israel: a 35-year epidemiological and clinical overview, 1981-2015.
Acquired immunodeficiency syndrome – AIDS
Gay men
Human immunodeficiency virus – HIV
Injecting drug users - IDU
Israel
Men who have sex with men – MSM
Journal
BMC public health
ISSN: 1471-2458
Titre abrégé: BMC Public Health
Pays: England
ID NLM: 100968562
Informations de publication
Date de publication:
13 Jun 2019
13 Jun 2019
Historique:
received:
08
08
2018
accepted:
17
05
2019
entrez:
15
6
2019
pubmed:
15
6
2019
medline:
23
8
2019
Statut:
epublish
Résumé
This study is the first to describe major epidemiological trends and clinical characteristics among Israeli men who have sex with men (MSM), who are at a higher risk for HIV infection. This retrospective study includes all individuals reported to the Israeli Ministry of Health with HIV and self-identified as MSM between 1981 and 2015. The incidence rates of HIV infection and AIDS-defining diseases were analyzed and Kaplan-Meier survival estimates were calculated from time of HIV infection notification to AIDS diagnosis and death across three consecutive periods representing antiretroviral treatment availability. The trend of increase in HIV incidence is similar to Western Europe, although Israeli rates are lower. Of 2052 HIV/AIDS Israeli MSM diagnosed during the follow-up, 296 (14.6%) developed AIDS. MSM constitute 28.4% of all HIV/AIDS cases and 41.5% of cases among men. Average times from HIV-notification until AIDS diagnosis were 15.5 [14.0-16.9], 16.0 [15.5-16.4], and 6.7 [6.7-6.8] years, within 1981-1996, 1997-2007, and 2008-2015, respectively. The HIV-incidence rate among Israeli MSM slightly declined from 2012, after peaking in 2011 at 6.2 per 100,000. The recent reduction in HIV-incidence and in AIDS diagnoses among Israeli MSM is encouraging. Nevertheless, the disproportionate incidence of HIV among MSM requires sustained efforts to abate further infections.
Sections du résumé
BACKGROUND
BACKGROUND
This study is the first to describe major epidemiological trends and clinical characteristics among Israeli men who have sex with men (MSM), who are at a higher risk for HIV infection.
METHODS
METHODS
This retrospective study includes all individuals reported to the Israeli Ministry of Health with HIV and self-identified as MSM between 1981 and 2015. The incidence rates of HIV infection and AIDS-defining diseases were analyzed and Kaplan-Meier survival estimates were calculated from time of HIV infection notification to AIDS diagnosis and death across three consecutive periods representing antiretroviral treatment availability.
RESULTS
RESULTS
The trend of increase in HIV incidence is similar to Western Europe, although Israeli rates are lower. Of 2052 HIV/AIDS Israeli MSM diagnosed during the follow-up, 296 (14.6%) developed AIDS. MSM constitute 28.4% of all HIV/AIDS cases and 41.5% of cases among men. Average times from HIV-notification until AIDS diagnosis were 15.5 [14.0-16.9], 16.0 [15.5-16.4], and 6.7 [6.7-6.8] years, within 1981-1996, 1997-2007, and 2008-2015, respectively. The HIV-incidence rate among Israeli MSM slightly declined from 2012, after peaking in 2011 at 6.2 per 100,000.
CONCLUSIONS
CONCLUSIONS
The recent reduction in HIV-incidence and in AIDS diagnoses among Israeli MSM is encouraging. Nevertheless, the disproportionate incidence of HIV among MSM requires sustained efforts to abate further infections.
Identifiants
pubmed: 31196014
doi: 10.1186/s12889-019-7000-1
pii: 10.1186/s12889-019-7000-1
pmc: PMC6567630
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
747Références
Biomed Pharmacother. 1999 Mar;53(2):63-72
pubmed: 10337460
Int J STD AIDS. 2004 Oct;15(10):691-6
pubmed: 15479507
J Acquir Immune Defic Syndr. 2006 Feb 1;41(2):194-200
pubmed: 16394852
AIDS Care. 2007 Apr;19(4):523-31
pubmed: 17453593
Harefuah. 2007 Dec;146(12):957-63, 997
pubmed: 18254449
AIDS Behav. 2008 Nov;12(6):835-41
pubmed: 18800244
Int J STD AIDS. 2008 Oct;19(10):698-703
pubmed: 18824624
JAMA. 2008 Oct 8;300(14):1674-84
pubmed: 18840841
J Antimicrob Chemother. 2009 Sep;64(3):599-606
pubmed: 19602563
Ann Ist Super Sanita. 2011;47(1):44-8
pubmed: 21430338
Clin Infect Dis. 2011 Jun;52(11):1363-70
pubmed: 21596678
Sex Transm Infect. 2011 Oct;87(6):532-7
pubmed: 21917699
Isr Med Assoc J. 2012 Mar;14(3):152-6
pubmed: 22675853
EMBO Rep. 2012 Nov 6;13(11):948-53
pubmed: 23070365
BMC Infect Dis. 2012 Nov 12;12:296
pubmed: 23145925
BMC Public Health. 2013 Feb 17;13:144
pubmed: 23414557
BMJ Open. 2013 Jul 06;3(7):null
pubmed: 23833144
Infect Dis Clin North Am. 2014 Sep;28(3):371-402
pubmed: 25151562
Isr J Health Policy Res. 2015 Aug 04;4:36
pubmed: 26244087
J Acquir Immune Defic Syndr. 2016 May 1;72(1):79-86
pubmed: 26745827
AIDS Behav. 2017 Feb;21(2):561-575
pubmed: 27498198
J Infect Dis. 2016 Sep 15;214(6):862-72
pubmed: 27559122
N Engl J Med. 1998 Mar 26;338(13):853-60
pubmed: 9516219
JAMA. 1998 Nov 4;280(17):1497-503
pubmed: 9809730