A review on hepatitis D: From virology to new therapies.
Chronic hepatitis
Epidemiology
Hepatitis delta management
Hepatitis delta virus
Treatment
Virus life cycle
Journal
Journal of advanced research
ISSN: 2090-1232
Titre abrégé: J Adv Res
Pays: Egypt
ID NLM: 101546952
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
02
01
2019
revised:
21
03
2019
accepted:
22
03
2019
entrez:
14
6
2019
pubmed:
14
6
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Hepatitis delta virus (HDV) is a defective virus that requires the hepatitis B virus (HBV) to complete its life cycle in human hepatocytes. HDV virions contain an envelope incorporating HBV surface antigen protein and a ribonucleoprotein containing the viral circular single-stranded RNA genome associated with both forms of hepatitis delta antigen, the only viral encoded protein. Replication is mediated by the host cell DNA-dependent RNA polymerases. HDV infects up to72 million people worldwide and is associated with an increased risk of severe and rapidly progressive liver disease. Pegylated interferon-alpha is still the only available treatment for chronic hepatitis D, with poor tolerance and dismal success rate. Although the development of antivirals inhibiting the viral replication is challenging, as HDV does not possess its own polymerase, several antiviral molecules targeting other steps of the viral life cycle are currently under clinical development: Myrcludex B, which blocks HDV entry into hepatocytes, lonafarnib, a prenylation inhibitor that prevents virion assembly, and finally REP 2139, which is thought to inhibit HBsAg release from hepatocytes and interact with hepatitis delta antigen. This review updates the epidemiology, virology and management of HDV infection.
Identifiants
pubmed: 31193285
doi: 10.1016/j.jare.2019.03.009
pii: S2090-1232(19)30075-X
pmc: PMC6526199
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
3-15Références
J Hepatol. 1999 Apr;30(4):564-9
pubmed: 10207796
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):424-9
pubmed: 10618434
Gut. 2000 Mar;46(3):420-6
pubmed: 10673308
J Virol. 2000 Aug;74(16):7204-10
pubmed: 10906174
J Virol. 2000 Aug;74(16):7375-80
pubmed: 10906190
Mol Cell Biol. 2000 Aug;20(16):6030-9
pubmed: 10913185
Science. 2001 Jul 6;293(5527):124-7
pubmed: 11387440
J Virol. 2002 Apr;76(8):3709-19
pubmed: 11907210
J Virol. 2002 Apr;76(8):3928-35
pubmed: 11907232
RNA. 2002 May;8(5):637-46
pubmed: 12022230
J Hepatol. 2002 Aug;37(2):266-71
pubmed: 12127433
J Virol. 2002 Oct;76(20):10465-72
pubmed: 12239323
J Biomed Sci. 1997;4(5):208-216
pubmed: 12386382
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15118-23
pubmed: 12399548
J Clin Invest. 2003 Aug;112(3):407-14
pubmed: 12897208
J Virol. 2003 Oct;77(19):10314-26
pubmed: 12970416
Nucleic Acids Res. 2003 Nov 15;31(22):6481-92
pubmed: 14602906
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6669-74
pubmed: 15100412
Gastroenterology. 2004 Jun;126(7):1740-9
pubmed: 15188169
J Hepatol. 2004 Oct;41(4):667-72
pubmed: 15464249
J Viral Hepat. 2005 Jan;12(1):2-9
pubmed: 15655042
Science. 1992 May 29;256(5061):1331-3
pubmed: 1598578
Antivir Ther. 2005;10(6):721-6
pubmed: 16218171
J Viral Hepat. 2006 Mar;13(3):150-7
pubmed: 16475990
Gastroenterology. 2006 May;130(6):1625-35
pubmed: 16697726
Curr Top Microbiol Immunol. 2006;307:151-71
pubmed: 16903225
Liver Int. 2006 Sep;26(7):805-10
pubmed: 16911462
Hepatology. 2006 Sep;44(3):713-20
pubmed: 16941685
Hepatology. 2006 Sep;44(3):728-35
pubmed: 16941695
Virology. 2007 Jan 5;357(1):68-78
pubmed: 16959288
Clin Infect Dis. 2007 Feb 1;44(3):e17-24
pubmed: 17205431
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10205-10
pubmed: 17551004
J Virol. 2007 Dec;81(23):13057-66
pubmed: 17898062
Hepatology. 2007 Dec;46(6):1759-68
pubmed: 18046710
Cell Microbiol. 2008 Jan;10(1):122-33
pubmed: 18086046
J Viral Hepat. 2008 Apr;15(4):314-21
pubmed: 18307594
J Virol. 1991 Mar;65(3):1099-104
pubmed: 1847439
Hepatology. 2009 Feb;49(2):398-406
pubmed: 19085955
Gastroenterology. 2009 May;136(5):1629-38
pubmed: 19208358
Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8490-4
pubmed: 1924308
Virology. 2009 Mar 30;386(1):12-5
pubmed: 19246067
J Gen Virol. 2009 Nov;90(Pt 11):2638-43
pubmed: 19605587
J Gen Virol. 2009 Nov;90(Pt 11):2759-67
pubmed: 19625466
Adv Virus Res. 2009;74:103-21
pubmed: 19698896
RNA. 2009 Nov;15(11):1971-9
pubmed: 19776158
J Virol. 2010 Feb;84(3):1430-8
pubmed: 19923176
J Hepatol. 2010 May;52(5):658-64
pubmed: 20346531
J Viral Hepat. 2011 Jun;18(6):415-23
pubmed: 20626626
J Viral Hepat. 2010 Nov;17(11):749-56
pubmed: 20723036
J Hepatol. 1990;11 Suppl 1:S151-4
pubmed: 2079575
J Hepatol. 2010 Nov;53(5):834-40
pubmed: 20800919
Liver Int. 2011 Jan;31(1):7-21
pubmed: 20880077
J Virol. 2011 Jan;85(1):432-9
pubmed: 20962099
J Infect Dis. 1990 Nov;162(5):1170-2
pubmed: 2121838
N Engl J Med. 2011 Jan 27;364(4):322-31
pubmed: 21268724
Curr Top Microbiol Immunol. 2012;353:123-43
pubmed: 21732238
Hepatology. 2012 Mar;55(3):685-94
pubmed: 22031488
Cochrane Database Syst Rev. 2011 Dec 07;(12):CD006002
pubmed: 22161394
J Gastrointestin Liver Dis. 2011 Dec;20(4):377-82
pubmed: 22187703
J Natl Cancer Inst. 2012 May 16;104(10):790-2
pubmed: 22423008
Semin Liver Dis. 2012 Aug;32(3):228-36
pubmed: 22932971
Semin Liver Dis. 2012 Aug;32(3):256-61
pubmed: 22932974
Clin Gastroenterol Hepatol. 2013 Jun;11(6):734-40
pubmed: 23376798
PLoS One. 2013;8(3):e58340
pubmed: 23505490
Hepat Mon. 2013 Jan;13(1):e8210
pubmed: 23554822
Curr Gastroenterol Rep. 2014 Jan;16(1):365
pubmed: 24293018
Proc Natl Acad Sci U S A. 1986 Nov;83(22):8774-8
pubmed: 2430299
Gastroenterology. 2014 Apr;146(4):1070-83
pubmed: 24361467
J Clin Virol. 2014 Feb;59(2):126-8
pubmed: 24365475
World J Hepatol. 2013 Dec 27;5(12):666-75
pubmed: 24409335
Antivir Ther. 2014;19(5):463-8
pubmed: 24423484
Hepatology. 2014 Jul;60(1):87-97
pubmed: 24585488
J Virol. 2014 May;88(10):5742-54
pubmed: 24623409
J Virol. 2014 Jun;88(11):6255-67
pubmed: 24648462
PLoS One. 2014 Mar 21;9(3):e92062
pubmed: 24658127
World J Gastroenterol. 2014 Mar 21;20(11):2971-8
pubmed: 24659888
J Virol. 2014 Jul;88(13):7402-11
pubmed: 24741096
Gastroenterology. 2014 Jul;147(1):48-64
pubmed: 24768844
World J Gastroenterol. 2014 Jun 28;20(24):7635-43
pubmed: 24976701
World J Gastroenterol. 2014 Jun 28;20(24):7665-74
pubmed: 24976704
PLoS One. 2014 Jul 29;9(7):e101002
pubmed: 25072849
AIDS. 2014 Oct 23;28(16):2389-94
pubmed: 25111082
Elife. 2012 Nov 13;3:null
pubmed: 25409679
J Hepatol. 2015 Aug;63(2):346-53
pubmed: 25795587
J Hepatol. 2015 Sep;63(3):586-92
pubmed: 25962883
Lancet Infect Dis. 2015 Oct;15(10):1167-1174
pubmed: 26189433
J Hepatol. 2015 Dec;63(6):1314-22
pubmed: 26216533
Hepatology. 2016 Jan;63(1):35-48
pubmed: 26224662
Lancet. 2015 Oct 17;386(10003):1546-55
pubmed: 26231459
Antiviral Res. 2015 Oct;122:112-29
pubmed: 26275800
World J Gastroenterol. 2015 Aug 28;21(32):9461-5
pubmed: 26327754
J Virol. 1989 May;63(5):1945-50
pubmed: 2649689
J Gastrointestin Liver Dis. 2015 Dec;24(4):413-21
pubmed: 26697566
J Hepatol. 2016 May;64(5):1011-1019
pubmed: 26739688
Curr Opin Virol. 2016 Apr;17:87-94
pubmed: 26897654
J Hepatol. 1989 Nov;9(3):338-44
pubmed: 2691569
Int J Infect Dis. 2016 May;46:82-8
pubmed: 27005283
J Hepatol. 2016 Apr;64(1 Suppl):S102-S116
pubmed: 27084031
J Hepatol. 2016 Sep;65(3):490-8
pubmed: 27132170
World J Hepatol. 2016 May 18;8(14):625-31
pubmed: 27190579
Hepatology. 2016 Nov;64(5):1483-1494
pubmed: 27530084
J Hepatol. 2017 Feb;66(2):297-303
pubmed: 27746337
Antiviral Res. 2016 Dec;136:19-31
pubmed: 27771387
Infection. 2017 Jun;45(3):277-281
pubmed: 27817147
Hepatology. 2017 Dec;66(6):1739-1749
pubmed: 27880976
J Clin Microbiol. 2017 Feb;55(2):431-441
pubmed: 27881614
J Hepatol. 2017 May;66(5):897-909
pubmed: 28043874
Viruses. 2017 Apr 10;9(4):
pubmed: 28394272
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875
World J Virol. 2017 May 12;6(2):26-35
pubmed: 28573087
Sci Rep. 2017 Jun 16;7(1):3757
pubmed: 28623307
Liver Int. 2018 May;38(5):842-850
pubmed: 28963781
Lancet Gastroenterol Hepatol. 2017 Dec;2(12):877-889
pubmed: 28964701
Hepatology. 2018 Apr;67(4):1224-1236
pubmed: 29152762
Gut. 2019 Jan;68(1):150-157
pubmed: 29217749
J Gastroenterol Hepatol. 2018 Jul;33(7):1389-1396
pubmed: 29266382
J Virol. 1989 Apr;63(4):1612-8
pubmed: 2926865
Hepatology. 2018 Apr;67(4):1560-1599
pubmed: 29405329
Gastroenterology. 2018 May;154(6):1778-1790
pubmed: 29408639
Gastroenterology. 2018 May;154(6):1791-1804.e22
pubmed: 29410097
J Virol. 2018 Apr 27;92(10):
pubmed: 29491161
J Hepatol. 2018 Jul;69(1):25-35
pubmed: 29524530
Lancet Gastroenterol Hepatol. 2018 Jun;3(6):383-403
pubmed: 29599078
Eur J Gastroenterol Hepatol. 2018 Sep;30(9):1060-1062
pubmed: 29742524
Biotechnol Genet Eng Rev. 2018 Apr;34(1):139-151
pubmed: 29785877
J Infect Dis. 2018 May 25;217(12):1902-1906
pubmed: 29800369
Sci Rep. 2018 Aug 2;8(1):11617
pubmed: 30072752
J Viral Hepat. 2019 Jan;26(1):170-182
pubmed: 30141209
Biochem Cell Biol. 2019 Apr;97(2):130-139
pubmed: 30153423
ACS Infect Dis. 2019 May 10;5(5):675-687
pubmed: 30199230
Gut. 2018 Sep 18;:null
pubmed: 30228220
J Gen Virol. 2018 Dec;99(12):1565-1566
pubmed: 30311870
Gut. 2018 Oct 27;:null
pubmed: 30368454
Med Sci (Paris). 2018 Oct;34(10):833-841
pubmed: 30451678
Viruses. 2018 Dec 17;10(12):
pubmed: 30562970
Gut. 2018 Dec 19;:null
pubmed: 30567743
Rev Soc Bras Med Trop. 2019 Jan 24;52:e20180289
pubmed: 30698197
J Viral Hepat. 2019 Jun;26(6):618-626
pubmed: 30771261
Antiviral Res. 2019 Apr;164:97-105
pubmed: 30771404
Lancet Infect Dis. 2019 Mar;19(3):275-286
pubmed: 30833068
MBio. 2019 Apr 2;10(2):
pubmed: 30940697
J Virol. 1988 Dec;62(12):4439-44
pubmed: 3184270
J Infect Dis. 1987 May;155(5):931-5
pubmed: 3559292
J Virol. 1986 Jun;58(3):945-50
pubmed: 3701932
Nature. 1986 Oct 9-15;323(6088):508-14
pubmed: 3762705
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6124-8
pubmed: 6934539
Nature. 1981 May 28;291(5813):297-301
pubmed: 7231549
Gut. 1977 Dec;18(12):997-1003
pubmed: 75123
J Virol. 1994 Jun;68(6):4063-6
pubmed: 8189544
J Virol. 1993 Dec;67(12):7659-62
pubmed: 8230486
J Virol. 1993 Jan;67(1):366-72
pubmed: 8416375
J Infect Dis. 1996 Nov;174(5):920-6
pubmed: 8896491
Structure. 1998 Jul 15;6(7):821-30
pubmed: 9687364