Tapentadol: an effective option for the treatment of back pain.
low back pain
neck pain
tapentadol
Journal
Journal of pain research
ISSN: 1178-7090
Titre abrégé: J Pain Res
Pays: New Zealand
ID NLM: 101540514
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
14
6
2019
pubmed:
14
6
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Back pain, including low back pain and neck pain, is the leading cause of disability worldwide. This type of pain is challenging to treat, since it presents both a nociceptive and a neuropathic component. The latter also contributes to the evolution of pain toward chronification. Treatment selection should therefore consider the ability to prevent this event. Tapentadol is characterized by a unique and innovative peculiar mechanism of action that makes it the first representative of a new class of central strong analgesics referred to as MOR-NRI. This molecule acts both on the nociceptive and neuropathic components of pain, and it can therefore be effective in the treatment of a mixed pain condition such as back pain. This narrative review discusses the rationale for the use of tapentadol in both low back pain and neck pain and presents available clinical data. Overall, data show that tapentadol prolonged release is a well-grounded treatment for chronic back pain, sustained by a strong mechanistic rationale and robust evidence. Given also the availability of long-term efficacy and safety data, we believe that this molecule should be considered as an elective therapy for chronic back pain.
Identifiants
pubmed: 31190963
doi: 10.2147/JPR.S190176
pii: jpr-12-1521
pmc: PMC6526923
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1521-1528Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
Disclosure FC served as speaker for Grunenthal and received speaker’s and/or consultancy fees from Grunenthal and Angelini. UF received consultancy fee from Grunenthal. The other authors report no conflicts of interest in this work.
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