Indoxyl Sulfate Induces Renal Fibroblast Activation through a Targetable Heat Shock Protein 90-Dependent Pathway.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2019
2019
Historique:
received:
17
12
2018
accepted:
12
03
2019
entrez:
11
6
2019
pubmed:
11
6
2019
medline:
17
1
2020
Statut:
epublish
Résumé
Indoxyl sulfate (IS) accumulation occurs early during chronic kidney disease (CKD) progression and contributes to renal dysfunction by inducing fibrosis, inflammation, oxidative stress, and tissue remodeling. Renal toxicity of high IS concentrations (250
Identifiants
pubmed: 31178953
doi: 10.1155/2019/2050183
pmc: PMC6501427
doi:
Substances chimiques
HSP90 Heat-Shock Proteins
0
Indican
N187WK1Y1J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2050183Références
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