Potential differences in cognition by race/ethnicity among persons with multiple sclerosis in a clinical setting: A preliminary study.
Adult
Black or African American
/ ethnology
Attention
/ physiology
Case-Control Studies
Cognition
/ physiology
Cognition Disorders
/ complications
Ethnicity
/ psychology
Female
Hispanic or Latino
/ psychology
Humans
Male
Middle Aged
Multiple Sclerosis
/ diagnosis
Neuropsychological Tests
Racial Groups
/ psychology
White People
/ ethnology
MACFIMS
Multiple sclerosis
cognitive dysfunction
ethnicity
Journal
NeuroRehabilitation
ISSN: 1878-6448
Titre abrégé: NeuroRehabilitation
Pays: Netherlands
ID NLM: 9113791
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
10
6
2019
medline:
28
8
2019
entrez:
10
6
2019
Statut:
ppublish
Résumé
While there is evidence of differences in the disease characteristics of multiple sclerosis (MS) across ethnic and racial groups, there has been limited research on cognitive functioning. To explore potential differences among Caucasian (CA), African-American (AA), and Hispanic (HA) adults from a clinical sample on the Minimal Assessment of Cognitive Function in MS (MACFIMS). A total of 245 age- and disease duration-matched individuals (194 CA, 23 AA, and 28 HA) were included in the analyses. Their rates of impairment, using the criterion of two standard deviations (SD) below the normative mean, on the MACFIMS were compared using chi-square analyses with post-hoc pairwise comparisons (Bonferroni adjusted). Compared to CA, AA had higher rates of impairment on measures of complex attention (p < 0.001) and executive functions (p < 0.001). These findings raise questions of whether the observed differences reflect the more aggressive disease course noted among AA or are due to discrepancies in performance on neuropsychological assessment that is associated with race/ethnicity in the general population. Future directions and implications are discussed.
Sections du résumé
BACKGROUND
BACKGROUND
While there is evidence of differences in the disease characteristics of multiple sclerosis (MS) across ethnic and racial groups, there has been limited research on cognitive functioning.
OBJECTIVE
OBJECTIVE
To explore potential differences among Caucasian (CA), African-American (AA), and Hispanic (HA) adults from a clinical sample on the Minimal Assessment of Cognitive Function in MS (MACFIMS).
METHODS
METHODS
A total of 245 age- and disease duration-matched individuals (194 CA, 23 AA, and 28 HA) were included in the analyses. Their rates of impairment, using the criterion of two standard deviations (SD) below the normative mean, on the MACFIMS were compared using chi-square analyses with post-hoc pairwise comparisons (Bonferroni adjusted).
RESULTS
RESULTS
Compared to CA, AA had higher rates of impairment on measures of complex attention (p < 0.001) and executive functions (p < 0.001).
CONCLUSIONS
CONCLUSIONS
These findings raise questions of whether the observed differences reflect the more aggressive disease course noted among AA or are due to discrepancies in performance on neuropsychological assessment that is associated with race/ethnicity in the general population. Future directions and implications are discussed.
Identifiants
pubmed: 31177245
pii: NRE182654
doi: 10.3233/NRE-182654
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM