Generation of a human iPS cell line (CABi003-A) from a patient with age-related macular degeneration carrying the CFH Y402H polymorphism.
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
25
04
2019
revised:
21
05
2019
accepted:
28
05
2019
pubmed:
10
6
2019
medline:
22
4
2020
entrez:
10
6
2019
Statut:
ppublish
Résumé
Age-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and is characterized by progressive degeneration of the macula, the central region of the retina. A human induced pluripotent stem cell (hiPSC) line was derived from peripheral blood mononuclear cells (PBMCs) from a patient with a clinical diagnosis of dry AMD carrying the CFH Y402H polymorphism. Sendai virus was using for reprogramming and the pluripotent and differentiation capacity of the cells were assessed by immunocytochemistry and RT-PCR.
Identifiants
pubmed: 31176916
pii: S1873-5061(19)30103-5
doi: 10.1016/j.scr.2019.101473
pii:
doi:
Substances chimiques
CFH protein, human
0
Complement Factor H
80295-65-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101473Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.