Porencephaly and Periventricular Encephalitis in a 4-month-old Puppy: Detection of Canine Parvovirus Type 2 and Potential Role in Brain Lesions.
canine parvovirus
immunohistochemistry
periventricular encephalitis
porencephaly
Journal
Journal of comparative pathology
ISSN: 1532-3129
Titre abrégé: J Comp Pathol
Pays: England
ID NLM: 0102444
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
13
12
2018
revised:
15
03
2019
accepted:
20
03
2019
entrez:
5
6
2019
pubmed:
5
6
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
A 4-month-old puppy died after showing intracranial signs a few days after a suspected viral enteritis. Grossly, the right cerebral hemisphere had a large irregular cavity external to the internal capsule. Histopathological examination revealed a cystic lesion in the right hemisphere and non-suppurative inflammation of the diencephalon and periaqueductal nervous tissue. Porencephaly associated with periventricular non-suppurative encephalitis was diagnosed. A nested polymerase chain reaction (PCR) identified the presence of parvovirus DNA in the brain and real-time PCR typed this as canine parvovirus (CPV) type 2a. Immunohistochemistry revealed the presence of CPV antigen in the cytoplasm of scattered cells in the subependymal layers and choroid plexus epithelium. The porencephaly was not associated with inflammatory lesions or CPV antigen and was considered to have preceded the neurological signs. In contrast, the detection of CPV antigen in the subependymal layers and choroid plexus epithelium supported the association of this virus with the periventricular encephalitis.
Identifiants
pubmed: 31159946
pii: S0021-9975(18)30525-5
doi: 10.1016/j.jcpa.2019.03.005
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-24Informations de copyright
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