Implications of Frailty for Peritransplant Outcomes in Kidney Transplant Recipients.
Assessment
Frailty
Kidney transplant
Outcomes
Prehabilitation
Survival
Journal
Current transplantation reports
ISSN: 2196-3029
Titre abrégé: Curr Transplant Rep
Pays: Switzerland
ID NLM: 101624626
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
entrez:
28
5
2019
pubmed:
28
5
2019
medline:
28
5
2019
Statut:
ppublish
Résumé
Research over the past few decades points to the importance of frailty, or the lack of physiologic reserve, in the natural history of chronic diseases and in modifying the impact of potential interventions. End-stage kidney disease (ESKD) and the intervention of kidney transplantation are no exception. We review the recent epidemiologic and cohort-based evidence on the association between frailty and kidney transplant outcomes and provide a framework of questions with which to approach future research endeavors and clinical practice. Frailty in kidney transplant candidates can be measured in numerous ways, including descriptive phenotype, description scores, functional testing, and surrogate measures. Regardless of the metric, the presence of frailty is strongly associated with inferior pre- and posttransplant outcomes compared to the absence of frailty. However, some frail patients with ESKD can benefit from transplant over chronic dialysis. Evidence-based approaches for identifying frail ESKD patients who can benefit from transplant over dialysis, with acceptable posttransplant outcomes, are lacking. Interventional trials to improve frailty and physical function before transplant (prehabilitation) and after transplant (rehabilitation) are also lacking. Frailty is increasingly recognized as highly relevant to peritransplant outcomes, but more work is needed to: 1) tailor management to the unique needs of frail patients, both pre- and posttransplant; 2) define phenotypes of frail patients who are expected to benefit from transplant over dialysis; and 3) develop interventions to reverse frailty, both pre- and post-transplant.
Identifiants
pubmed: 31131186
doi: 10.1007/s40472-019-0227-z
pmc: PMC6529948
mid: NIHMS1023408
doi:
Types de publication
Journal Article
Langues
eng
Pagination
16-25Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR002241
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102981
Pays : United States
Déclaration de conflit d'intérêts
Compliance with Ethical Standards Conflict of Interest Xingxing S. Cheng, Krista L. Lentine, Farrukh M. Koraishy, Jonathan Myers, and Jane C. Tan report no conflicts of interest or funding for this work. XSC, KLL and JCT are members of the Frailty Consensus workgroup formed by the American Society of Transplantation (AST) Kidney-Pancreas Community of Practice; KLL is the American Society of Nephrology (ASN) Quality Committee representative to the workgroup.
Références
Lancet. 2013 Mar 2;381(9868):752-62
pubmed: 23395245
J Am Soc Nephrol. 2018 Jun;29(6):1752-1759
pubmed: 29685884
J Am Geriatr Soc. 2013 Jun;61(6):896-901
pubmed: 23711111
Am J Kidney Dis. 2015 Nov;66(5):837-45
pubmed: 26162652
Am J Transplant. 2014 Aug;14(8):1922-6
pubmed: 24903739
Clin J Am Soc Nephrol. 2016 Jun 6;11(6):1024-33
pubmed: 27026522
J Gerontol. 1994 Mar;49(2):M85-94
pubmed: 8126356
Arch Surg. 2012 Feb;147(2):190-3
pubmed: 22351919
Am J Transplant. 2018 Jan;18 Suppl 1:18-113
pubmed: 29292608
Transplantation. 2018 Feb;102(2):291-299
pubmed: 28885489
Am J Transplant. 2015 Jan;15(1):149-54
pubmed: 25359393
Am J Transplant. 2017 Apr;17(4):1031-1041
pubmed: 27664797
J Am Soc Nephrol. 2017 Apr;28(4):1259-1268
pubmed: 27909047
Transplantation. 2017 Sep;101(9):2126-2132
pubmed: 27779573
BMC Geriatr. 2002 Feb 27;2:1
pubmed: 11897015
Can Med Assoc J. 1985 Apr 15;132(8):919-23
pubmed: 3978515
Clin Transplant. 2017 Mar;31(3):
pubmed: 28075034
J Am Soc Nephrol. 2007 Nov;18(11):2960-7
pubmed: 17942958
Int Urol Nephrol. 2007;39(4):1303-11
pubmed: 17902035
Transplantation. 2002 Jul 15;74(1):42-8
pubmed: 12134097
J Am Soc Nephrol. 2014 Jan;25(1):187-95
pubmed: 24231666
Ann Surg. 2010 Oct;252(4):662-74
pubmed: 20881773
Clin J Am Soc Nephrol. 2016 Apr 7;11(4):626-32
pubmed: 26792529
Age Ageing. 2017 May 1;46(3):383-392
pubmed: 28064173
Transplantation. 2015 Apr;99(4):805-10
pubmed: 25393156
Clin Transplant. 2017 Aug;31(8):
pubmed: 28564126
Ann Surg. 2017 Dec;266(6):1084-1090
pubmed: 27655240
Ann Surg. 2016 Dec;264(6):1168-1173
pubmed: 26720436
J Am Geriatr Soc. 2015 Oct;63(10):2152-7
pubmed: 26416770
Transplantation. 2018 Oct;102(10):1740-1746
pubmed: 29677074
Am J Transplant. 2018 Jan;18(1):189-196
pubmed: 28710900
BMC Nephrol. 2016 Nov 24;17(1):192
pubmed: 27881101
Am J Kidney Dis. 2015 Oct;66(4):689-98
pubmed: 26209542
J Nutr Health Aging. 2012;16(9):769-74
pubmed: 23131819
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
Arch Intern Med. 2012 Jul 23;172(14):1071-7
pubmed: 22733312
Circulation. 2016 Dec 13;134(24):e653-e699
pubmed: 27881567
Am J Transplant. 2013 Aug;13(8):2091-5
pubmed: 23731461
Transplantation. 2019 Aug;103(8):1700-1704
pubmed: 31348438
Clin Transplant. 2018 Oct;32(10):e13391
pubmed: 30152107
Am J Nephrol. 2019;49(2):103-110
pubmed: 30625489
Transplantation. 2019 May;103(5):1051-1063
pubmed: 30086093
J Am Soc Nephrol. 2013 Feb;24(3):337-51
pubmed: 23264684
Clin J Am Soc Nephrol. 2018 Apr 6;13(4):628-637
pubmed: 29511059
Clin Transplant. 2017 Oct;31(10):
pubmed: 28758236
J Am Soc Nephrol. 2017 Oct;28(10):3014-3023
pubmed: 28592422