Domain I of β2GPI is capable of blocking serum IgA antiphospholipid antibodies binding in vitro: an effect enhanced by PEGylation.
Antibodies, Antiphospholipid
/ immunology
Antiphospholipid Syndrome
/ immunology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin A
/ immunology
London
Lupus Coagulation Inhibitor
/ immunology
Lupus Erythematosus, Systemic
/ complications
Male
Oxidation-Reduction
Turkey
beta 2-Glycoprotein I
/ metabolism
Antiphospholipid syndrome
Domain I
PEGylation
Journal
Lupus
ISSN: 1477-0962
Titre abrégé: Lupus
Pays: England
ID NLM: 9204265
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
pubmed:
28
5
2019
medline:
18
12
2019
entrez:
26
5
2019
Statut:
ppublish
Résumé
This study aims to inhibit antiphospholipid syndrome (APS) serum derived IgA anti-beta-2-glycoprotein I (aβ2GPI) binding using Domain I (DI). Serum from 13 APS patients was tested for IgA aβ2GPI and Anti-Domain I. Whole IgA was purified by peptide M affinity chromatography from positive serum samples. Serum was tested for IgA aβ2GPI binding in the presence and absence of either DI or of two biochemically modified variants containing either 20 kDa of poly(ethylene glycol) (PEG) or 40 kDa of PEG. Significant inhibition with DI was possible with average inhibition of 23% ( Inhibition of IgA aβ2GPI by DI is possible and can be enhanced by biochemical modification in a subset of patients.
Identifiants
pubmed: 31126213
doi: 10.1177/0961203319851571
pmc: PMC6567316
doi:
Substances chimiques
Antibodies, Antiphospholipid
0
Immunoglobulin A
0
Lupus Coagulation Inhibitor
0
beta 2-Glycoprotein I
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
893-897Subventions
Organisme : Versus Arthritis
ID : 19423
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21223
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 21992
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P017371/1
Pays : United Kingdom
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