Chimeric Mice with Deletion of

Actins / metabolism Animals Chimera Cofilin 2 / genetics Mice Mice, Knockout Muscle Development Muscle, Skeletal / metabolism Myocardium / metabolism Myofibrils / pathology Sarcomeres / metabolism
Cfl2 cardiac muscle chimeric mice cofilin cofilin-2 myofibril assembly

Journal

Zoological science
ISSN: 0289-0003
Titre abrégé: Zoolog Sci
Pays: Japan
ID NLM: 8702287

Informations de publication

Date de publication:
01 04 2019
Historique:
received: 20 09 2018
accepted: 23 11 2018
entrez: 24 5 2019
pubmed: 24 5 2019
medline: 6 6 2019
Statut: ppublish

Résumé

Cofilin, a member of the ADF/cofilin family, is an actin-binding protein which is widely distributed among eukaryotic organisms and involved in actin filament dynamics in a variety of cell types. In mammalian striated muscles, muscle-type cofilin (MCF or cofilin-2) is predominantly expressed. Previous investigations have shown that MCF plays an essential role in the regulation of assembly of contractile apparatus in skeletal muscle, but its role in cardiac muscle has remained unclear. In the present study, in order to further clarify the role of MCF in organization of myofibrillar structure in vivo, we generated chimeric mice with a combination of MCF-deficient cells that were generated by

Identifiants

DOI: 10.2108/zs180151 PMID: 31120645
pubmed: 31120645
doi: 10.2108/zs180151
doi:

Substances chimiques

Actins 0
Cofilin 2 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112-119

Informations de copyright

© 2019 Zoological Society of Japan.

Auteurs

Kurato Mohri (K)

Department of Biology, Graduate School of Science and Technology, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

Fumie Suzuki-Toyota (F)

Department of Anatomy and Developmental Biology, Graduate School of Medicine, Chiba University, Chiba 280-8670, Japan.

Takashi Obinata (T)

Department of Biology, Graduate School of Science and Technology, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

Naruki Sato (N)

Department of Biology, Graduate School of Science and Technology, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Department of Biology, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan, sato@faculty.chiba-u.jp.

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Classifications MeSH

Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › Chimeric Mice with Deletion of
Recherchemedicale.com › Eucaryotes › Animaux › Chimeric Mice with Deletion of
Recherchemedicale.com › Stades d'organismes › Chimère › Chimeric Mice with Deletion of
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Facteurs de dépolymérisation de l'actine › Cofiline-2 › Chimeric Mice with Deletion of
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Chimeric Mice with Deletion of
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Chimeric Mice with Deletion of
Recherchemedicale.com › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Développement musculaire › Chimeric Mice with Deletion of
Recherchemedicale.com › Tissus › Muscles › Muscle strié › Muscles squelettiques › Chimeric Mice with Deletion of
Recherchemedicale.com › Tissus › Muscles › Muscle strié › Myocarde › Chimeric Mice with Deletion of
Recherchemedicale.com › Cellules › Cellules musculaires › Myocytes cardiaques › Myofibrilles › Chimeric Mice with Deletion of
Recherchemedicale.com › Cellules › Cellules musculaires › Myocytes cardiaques › Myofibrilles › Sarcomères › Chimeric Mice with Deletion of