Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds.
Biological Sciences
Cell Biology
Glycobiology
Molecular Biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
31 May 2019
31 May 2019
Historique:
received:
20
02
2019
revised:
11
04
2019
accepted:
26
04
2019
pubmed:
20
5
2019
medline:
20
5
2019
entrez:
20
5
2019
Statut:
ppublish
Résumé
Heparanase is an endoglycosidase involved in remodeling the extracellular matrix and thereby in regulating multiple cellular processes and biological activities. It cleaves heparan sulfate (HS) side chains of HS proteoglycans into smaller fragments and hence regulates tissue morphogenesis, differentiation, and homeostasis. Heparanase is overexpressed in various carcinomas, sarcomas, and hematological malignancies, and its upregulation correlates with increased tumor size, tumor angiogenesis, enhanced metastasis, and poor prognosis. In contrast, knockdown or inhibition of heparanase markedly attenuates tumor progression, further underscoring the potential of anti-heparanase therapy. Heparanase inhibitors were employed to interfere with tumor progression in preclinical studies, and selected heparin mimetics are being examined in clinical trials. However, despite tremendous efforts, the discovery of heparanase inhibitors with high clinical benefit and minimal adverse effects remains a therapeutic challenge. This review discusses the key roles of heparanase in cancer progression focusing on the status of natural, chemically modified, and synthetic heparanase inhibitors in various types of malignancies.
Identifiants
pubmed: 31103854
pii: S2589-0042(19)30131-2
doi: 10.1016/j.isci.2019.04.034
pmc: PMC6548846
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
360-390Subventions
Organisme : NCI NIH HHS
ID : R01 CA211752
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Références
Cancer Res. 1999 Jul 15;59(14):3433-41
pubmed: 10416607
Curr Top Microbiol Immunol. 1999;243:123-36
pubmed: 10453641
Annu Rev Biochem. 1999;68:729-77
pubmed: 10872465
Biochim Biophys Acta. 2001 Mar 21;1471(3):M99-108
pubmed: 11250066
Clin Appl Thromb Hemost. 2001 Apr;7(2):131-40
pubmed: 11292191
Carbohydr Res. 2001 May 18;332(2):183-9
pubmed: 11434376
J Clin Invest. 2001 Aug;108(3):341-7
pubmed: 11489924
J Biol Chem. 2001 Dec 28;276(52):48644-54
pubmed: 11590140
Am J Pathol. 2002 Jan;160(1):185-94
pubmed: 11786412
Leukemia. 2002 Mar;16(3):376-81
pubmed: 11896541
Semin Cancer Biol. 2002 Apr;12(2):121-9
pubmed: 12027584
J Cell Physiol. 2002 Sep;192(3):276-85
pubmed: 12124773
J Neurol Sci. 2003 Jan 15;206(1):49-57
pubmed: 12480085
Int J Cancer. 2003 Mar 20;104(2):167-74
pubmed: 12569571
Biochem Biophys Res Commun. 1976 Dec 6;73(3):569-76
pubmed: 137724
J Med Chem. 2003 Oct 9;46(21):4601-8
pubmed: 14521421
Oncogene. 2003 Oct 30;22(49):7737-49
pubmed: 14586400
J Biol Chem. 2004 May 28;279(22):23536-41
pubmed: 15044433
J Antibiot (Tokyo). 2004 Feb;57(2):136-42
pubmed: 15112962
Bioorg Med Chem Lett. 2004 Jun 21;14(12):3269-73
pubmed: 15149688
J Biol Chem. 2004 Oct 15;279(42):44084-92
pubmed: 15292202
J Natl Cancer Inst. 2004 Aug 18;96(16):1219-30
pubmed: 15316057
Mol Cancer Ther. 2004 Sep;3(9):1069-77
pubmed: 15367701
Matrix Biol. 2004 Oct;23(6):341-52
pubmed: 15533755
J Biol Chem. 2005 Apr 1;280(13):12103-13
pubmed: 15647251
J Biol Chem. 2005 May 27;280(21):20457-66
pubmed: 15760902
Oncogene. 2005 Jun 9;24(25):4037-51
pubmed: 15806157
Bioorg Med Chem Lett. 2005 May 2;15(9):2295-9
pubmed: 15837312
Bioorg Med Chem Lett. 2006 Jan 15;16(2):404-8
pubmed: 16246551
Bioorg Med Chem Lett. 2006 Jan 15;16(2):409-12
pubmed: 16246560
J Med Chem. 2005 Dec 29;48(26):8229-36
pubmed: 16366604
Blood. 2006 May 1;107(9):3609-16
pubmed: 16384929
Treat Endocrinol. 2006;5(4):211-22
pubmed: 16879000
J Cell Biol. 2006 Jul 31;174(3):323-7
pubmed: 16880267
Int J Biochem Cell Biol. 2006;38(12):2018-39
pubmed: 16901744
Cancer Res. 2006 Sep 1;66(17):8779-87
pubmed: 16951194
Br J Pharmacol. 2007 May;151(1):1-14
pubmed: 17339837
J Thromb Haemost. 2007 Apr;5(4):729-37
pubmed: 17408406
Biol Reprod. 2007 Sep;77(3):433-41
pubmed: 17507691
Shock. 2007 Aug;28(2):207-12
pubmed: 17515848
Kidney Int. 2007 Sep;72(5):543-8
pubmed: 17519955
Semin Thromb Hemost. 2007 Jul;33(5):557-68
pubmed: 17629854
Cancer. 2007 Sep 1;110(5):1149-61
pubmed: 17634948
J Cell Mol Med. 2007 May-Jun;11(3):427-52
pubmed: 17635638
J Leukoc Biol. 2007 Nov;82(5):1289-300
pubmed: 17656651
J Agric Food Chem. 2007 Aug 22;55(17):6910-7
pubmed: 17661479
Bioorg Med Chem. 2008 Jan 15;16(2):699-709
pubmed: 17967543
Clin Exp Metastasis. 2008;25(2):149-59
pubmed: 18027090
J Biol Chem. 2008 Jun 27;283(26):18167-76
pubmed: 18450756
Arthritis Rheum. 2008 Jun;58(6):1590-600
pubmed: 18512775
Int J Cancer. 2008 Dec 1;123(11):2566-73
pubmed: 18798279
Exp Eye Res. 2009 May;88(5):848-58
pubmed: 18840430
Expert Opin Investig Drugs. 2008 Nov;17(11):1769-76
pubmed: 18922112
J Invest Dermatol. 2009 May;129(5):1192-202
pubmed: 19052560
Glycobiology. 2009 Apr;19(4):408-17
pubmed: 19106233
Pathophysiol Haemost Thromb. 2008;36(3-4):195-203
pubmed: 19176992
Clin Cancer Res. 2009 Feb 15;15(4):1210-21
pubmed: 19228727
Cancer Res. 2009 Mar 1;69(5):1758-67
pubmed: 19244131
Invest New Drugs. 2010 Jun;28(3):276-83
pubmed: 19357810
J Comput Aided Mol Des. 2009 Aug;23(8):555-69
pubmed: 19421720
Acta Pharmacol Sin. 2009 Jul;30(7):1033-8
pubmed: 19543297
Trends Biochem Sci. 2009 Oct;34(10):511-9
pubmed: 19733083
Anal Biochem. 2010 Jan 1;396(1):112-6
pubmed: 19748475
Glycobiology. 2010 Feb;20(2):175-86
pubmed: 19822709
Thromb Haemost. 2009 Nov;102(5):823-8
pubmed: 19888515
Int J Biochem Cell Biol. 2010 Feb;42(2):186-92
pubmed: 19914392
Haematologica. 2010 Jul;95(7):1144-9
pubmed: 20053869
Curr Opin Mol Ther. 2010 Feb;12(1):107-14
pubmed: 20140822
Acta Pharmacol Sin. 2010 Mar;31(3):375-81
pubmed: 20154712
J Biol Chem. 1991 May 25;266(15):9661-6
pubmed: 2033058
Exp Eye Res. 2010 Oct;91(4):476-7
pubmed: 20478306
Cancer Biol Ther. 2010 Jul 1;10(1):89-98
pubmed: 20495375
FASEB J. 2010 Dec;24(12):4969-76
pubmed: 20798248
Cancer Lett. 2010 Nov 28;297(2):231-43
pubmed: 20831981
Biopolymers. 2011 Feb;95(2):151-60
pubmed: 20882536
Cell Regul. 1990 Oct;1(11):833-42
pubmed: 2088528
J Cell Sci. 2010 Dec 15;123(Pt 24):4195-200
pubmed: 21123617
Clin Cancer Res. 2011 Mar 15;17(6):1382-93
pubmed: 21257720
Br J Cancer. 2011 Feb 15;104(4):635-42
pubmed: 21285983
Cancer Metastasis Rev. 2011 Jun;30(2):253-68
pubmed: 21308479
Int J Cancer. 2012 Jan 15;130(2):467-77
pubmed: 21387297
J Clin Invest. 2011 May;121(5):1709-21
pubmed: 21490396
Neoplasia. 2011 May;13(5):445-52
pubmed: 21532885
PLoS One. 2011;6(6):e21106
pubmed: 21698156
Cancer Microenviron. 2012 Aug;5(2):115-32
pubmed: 21811836
Lancet. 2011 Dec 17;378(9809):2081-7
pubmed: 22036019
Diabetes. 2012 Jan;61(1):208-16
pubmed: 22106160
Expert Opin Biol Ther. 2012 Mar;12(3):353-61
pubmed: 22283742
Lancet. 2012 Apr 28;379(9826):1602-12
pubmed: 22440946
J Med Chem. 2012 Apr 26;55(8):3804-13
pubmed: 22458531
PLoS One. 2012;7(6):e37938
pubmed: 22719856
Transcription. 2012 May-Jun;3(3):130-45
pubmed: 22771948
J Transl Med. 2012 Oct 24;10:213
pubmed: 23095131
PLoS One. 2012;7(12):e52175
pubmed: 23300607
FEBS J. 2013 May;280(10):2294-306
pubmed: 23374281
Bioorg Med Chem. 2013 Apr 1;21(7):1944-51
pubmed: 23415087
Biochem Pharmacol. 2013 May 15;85(10):1424-32
pubmed: 23466421
Matrix Biol. 2013 Jun 24;32(5):228-33
pubmed: 23499527
Matrix Biol. 2013 Jun 24;32(5):234-240
pubmed: 23499528
Matrix Biol. 2013 Jun 24;32(5):223-7
pubmed: 23499529
Matrix Biol. 2013 Jun 24;32(5):241-51
pubmed: 23499530
Mol Cancer Ther. 2013 Jul;12(7):1190-201
pubmed: 23696215
FEBS Open Bio. 2013 Aug 02;3:346-51
pubmed: 24251094
Anal Bioanal Chem. 2014 Jan;406(1):249-65
pubmed: 24253408
Biochem Biophys Res Commun. 2014 Jan 3;443(1):185-8
pubmed: 24291708
Biochim Biophys Acta. 2014 Apr;1845(2):136-54
pubmed: 24388873
Front Immunol. 2013 Dec 18;4:470
pubmed: 24391644
Nephrol Dial Transplant. 2014 Feb;29 Suppl 1:i74-i79
pubmed: 24493873
Can J Diabetes. 2013 Oct;37(5):332-8
pubmed: 24500561
Eur J Biochem. 1988 Mar 1;172(2):349-53
pubmed: 2450743
Eur J Pharmacol. 2014 Apr 5;728:151-60
pubmed: 24530413
Blood. 2014 May 8;123(19):2934-43
pubmed: 24620349
J Pharm Biomed Anal. 2014 Jul;95:130-8
pubmed: 24667567
Carbohydr Res. 2014 May 7;389:134-40
pubmed: 24680506
Leukemia. 2014 Nov;28(11):2178-87
pubmed: 24699306
J Thromb Haemost. 2014 Jul;12(7):1076-85
pubmed: 24796727
Cancer Res. 2014 Aug 15;74(16):4504-14
pubmed: 24970482
Front Oncol. 2014 Jul 24;4:195
pubmed: 25105093
PLoS One. 2014 Oct 08;9(10):e109596
pubmed: 25295599
PLoS One. 2014 Oct 08;9(10):e96846
pubmed: 25295847
J Biol Chem. 2014 Dec 5;289(49):34296-307
pubmed: 25320076
J Biol Chem. 2014 Dec 5;289(49):34141-51
pubmed: 25336655
Glycobiology. 2015 Apr;25(4):386-93
pubmed: 25367817
Oncotarget. 2015 Mar 10;6(7):4992-5004
pubmed: 25669977
Eur J Cancer. 2015 May;51(7):879-892
pubmed: 25754234
Ann Med. 2015 Mar;47(2):116-21
pubmed: 25766973
Nat Med. 2015 May;21(5):524-9
pubmed: 25849134
Carbohydr Polym. 2015 Jul 10;125:76-84
pubmed: 25857962
Bioorg Med Chem Lett. 2015 Aug 1;25(15):2931-6
pubmed: 26048794
Cancer Cell Int. 2015 May 13;15:52
pubmed: 26052253
Org Biomol Chem. 2015 Sep 28;13(36):9381-7
pubmed: 26159576
Cancer Res. 2015 Sep 15;75(18):3946-57
pubmed: 26249176
Biomol Concepts. 2015 Dec;6(5-6):415-21
pubmed: 26552066
Autophagy. 2015;11(12):2387-9
pubmed: 26571129
Nat Struct Mol Biol. 2015 Dec;22(12):1016-22
pubmed: 26575439
Oncotarget. 2016 Jan 12;7(2):1598-607
pubmed: 26624982
J Clin Invest. 2016 Jan;126(1):207-19
pubmed: 26649979
J Clin Oncol. 2016 Feb 10;34(5):488-94
pubmed: 26700124
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):704-9
pubmed: 26729870
Glycobiology. 2016 Jun;26(6):640-54
pubmed: 26762172
Am J Pathol. 2016 Apr;186(4):805-15
pubmed: 26873445
Matrix Biol. 2016 Sep;55:22-34
pubmed: 27016342
J Am Soc Nephrol. 2016 Dec;27(12):3545-3551
pubmed: 27026367
Future Med Chem. 2016 Apr;8(6):647-80
pubmed: 27057774
Oncotarget. 2016 Jun 14;7(24):36154-36167
pubmed: 27166252
Eur J Med Chem. 2016 Oct 4;121:209-220
pubmed: 27240275
ACS Cent Sci. 2016 May 25;2(5):351-8
pubmed: 27280170
Oncotarget. 2016 Jul 26;7(30):47848-47863
pubmed: 27374103
Pharmaceuticals (Basel). 2016 Jul 04;9(3):null
pubmed: 27384570
Int J Oncol. 2016 Sep;49(3):1221-9
pubmed: 27500741
J Am Coll Cardiol. 2016 Aug 30;68(9):967-76
pubmed: 27561771
Exp Hematol. 2016 Nov;44(11):1002-1012
pubmed: 27576132
PLoS One. 2016 Sep 29;11(9):e0163209
pubmed: 27685808
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7808-E7817
pubmed: 27849593
Drug Resist Updat. 2016 Nov;29:54-75
pubmed: 27912844
CA Cancer J Clin. 2017 Jan;67(1):7-30
pubmed: 28055103
J Antibiot (Tokyo). 2017 May;70(5):705-707
pubmed: 28096547
BMC Cancer. 2017 Mar 31;17(1):235
pubmed: 28359266
Carbohydr Polym. 2017 Jun 15;166:156-165
pubmed: 28385219
Sci Rep. 2017 Apr 12;7:46229
pubmed: 28401953
Mar Drugs. 2017 May 09;15(5):null
pubmed: 28486399
J Clin Invest. 2017 Jun 30;127(7):2777-2788
pubmed: 28581441
Nat Chem Biol. 2017 Aug;13(8):867-873
pubmed: 28581485
Bioorg Med Chem Lett. 2017 Aug 1;27(15):3349-3352
pubmed: 28624143
Clin Cancer Res. 2017 Oct 15;23(20):6267-6278
pubmed: 28710312
Mol Cancer Ther. 2017 Aug;16(8):1705-1716
pubmed: 28716813
Bioorg Med Chem Lett. 2017 Sep 15;27(18):4421-4425
pubmed: 28811133
Pharmaceuticals (Basel). 2017 Oct 02;10(4):null
pubmed: 28974047
Oncologist. 2017 Dec;22(12):1429-e139
pubmed: 29158367
Trends Biochem Sci. 2018 Jan;43(1):18-31
pubmed: 29162390
Cancer Lett. 2018 Feb 28;415:187-197
pubmed: 29225052
Methods Cell Biol. 2018;143:317-333
pubmed: 29310785
Antimicrob Agents Chemother. 2018 Mar 27;62(4):
pubmed: 29437628
Br J Cancer. 2018 Apr;118(8):1035-1041
pubmed: 29531325
J Natl Cancer Inst. 2018 Oct 1;110(10):1102-1114
pubmed: 29579286
Haematologica. 2018 Oct;103(10):e469-e472
pubmed: 29700168
Oncotarget. 2018 Apr 10;9(27):19294-19306
pubmed: 29721203
Front Pharmacol. 2018 Apr 26;9:309
pubmed: 29755344
J Immunother Cancer. 2018 Jun 14;6(1):54
pubmed: 29898788
J Med Chem. 2018 Aug 9;61(15):6918-6936
pubmed: 30010344
Cancer Prev Res (Phila). 2018 Oct;11(10):629-642
pubmed: 30021726
Exp Cell Res. 2018 Oct 1;371(1):151-161
pubmed: 30086306
Matrix Biol. 2019 Apr;77:58-72
pubmed: 30096360
Molecules. 2018 Nov 14;23(11):null
pubmed: 30441818
Front Pharmacol. 2018 Nov 05;9:1125
pubmed: 30455641
Atherosclerosis. 2019 Apr;283:127-136
pubmed: 30665614
Atherosclerosis. 2019 Apr;283:124-126
pubmed: 30745229
Am J Pathol. 1988 Feb;130(2):393-400
pubmed: 3277442
Int J Cancer. 1987 Oct 15;40(4):511-8
pubmed: 3666989
FEBS Lett. 1995 Sep 18;372(1):54-8
pubmed: 7556642
Annu Rev Biochem. 1995;64:763-97
pubmed: 7574500
Cancer Res. 1995 Nov 1;55(21):4957-61
pubmed: 7585536
Cancer Chemother Pharmacol. 1995;36(4):325-34
pubmed: 7628052
J Antibiot (Tokyo). 1995 May;48(5):357-62
pubmed: 7797435
J Biol Chem. 1975 Apr 10;250(7):2690-7
pubmed: 804478
J Clin Invest. 1997 Apr 1;99(7):1565-75
pubmed: 9120000
Cancer Lett. 1979 Nov;8(1):9-22
pubmed: 92362
Cancer Chemother Pharmacol. 1998;41(2):117-24
pubmed: 9443624
Curr Opin Chem Biol. 1997 Jun;1(1):5-9
pubmed: 9667829
J Biol Chem. 1998 Jul 24;273(30):18770-7
pubmed: 9668050