Sex-Dependent Effects of Perinatal Inflammation on the Brain: Implication for Neuro-Psychiatric Disorders.
Attention Deficit Disorder with Hyperactivity
/ physiopathology
Autism Spectrum Disorder
/ physiopathology
Brain
/ diagnostic imaging
Humans
Inflammation
/ diagnostic imaging
Neurodevelopmental Disorders
/ physiopathology
Neuroglia
/ pathology
Premature Birth
/ physiopathology
Schizophrenia
/ physiopathology
Sex Characteristics
microglia
neuroimmune
neuropsychiatry
perinatal
sex
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 May 2019
08 May 2019
Historique:
received:
22
04
2019
revised:
03
05
2019
accepted:
06
05
2019
entrez:
11
5
2019
pubmed:
11
5
2019
medline:
31
8
2019
Statut:
epublish
Résumé
Individuals born preterm have higher rates of neurodevelopmental disorders such as schizophrenia, autistic spectrum, and attention deficit/hyperactivity disorders. These conditions are often sexually dimorphic and with different developmental trajectories. The etiology is likely multifactorial, however, infections both during pregnancy and in childhood have emerged as important risk factors. The association between sex- and age-dependent vulnerability to neuropsychiatric disorders has been suggested to relate to immune activation in the brain, including complex interactions between sex hormones, brain transcriptome, activation of glia cells, and cytokine production. Here, we will review sex-dependent effects on brain development, including glia cells, both under normal physiological conditions and following perinatal inflammation. Emphasis will be given to sex-dependent effects on brain regions which play a role in neuropsychiatric disorders and inflammatory reactions that may underlie early-life programming of neurobehavioral disturbances later in life.
Identifiants
pubmed: 31071949
pii: ijms20092270
doi: 10.3390/ijms20092270
pmc: PMC6539135
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R21 NS098514
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139685
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103483
Pays : United States
Organisme : Vetenskapsrådet
ID : 2017-01409
Organisme : Government grant to a researcher in Public Health Service
ID : ALFGBG-722491
Organisme : National Institutes of Health
ID : RO1HL-139685-01
Organisme : Hjärnfonden
ID : FO2017-0063
Organisme : NINDS NIH HHS
ID : R01 NS044025
Pays : United States
Organisme : Åhlens Foundation
ID : 2018
Organisme : Foundation for the National Institutes of Health
ID : RO1NS103483-01A1
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