Subchronic toxicity of silica nanoparticles as a function of size and porosity.
Drug delivery
Inflammation
Physiochemical properties
Silica nanoparticles
Subchronic toxicity
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
28 06 2019
28 06 2019
Historique:
received:
08
02
2019
revised:
20
04
2019
accepted:
28
04
2019
pubmed:
3
5
2019
medline:
10
9
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
Despite increasing reports of using silica nanoparticles (SNPs) for controlled drug delivery applications, their long-term toxicity profile following intravenous administration remains unexplored. Herein, we investigated the acute (10-day) and subchronic (60-day and 180-day) toxicity of nonporous SNPs of approximately 50 nm (Stöber SNPs50) and approximately 500 nm in diameter (Stöber SNPs500), and mesoporous SNPs of approximately 500 nm in diameter (MSNPs500) upon single-dose intravenous injection into male and female immune-competent inbred BALB/c mice. The Maximum Tolerated Dose (MTD) of the particles was determined 10 days post-injection. The MTD of SNPs was administered and toxicity evaluated over 60 and 180 days. Results demonstrate that Stöber SNPs50 exhibit systemic toxicity with MTD of 103 ± 11 mg.kg
Identifiants
pubmed: 31047961
pii: S0168-3659(19)30244-5
doi: 10.1016/j.jconrel.2019.04.041
pmc: PMC6681828
mid: NIHMS1531305
pii:
doi:
Substances chimiques
Cytokines
0
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-232Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE019050
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES024681
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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