Mice Lacking Brain-Derived Serotonin Have Altered Swallowing Function.
5-hydroxytryptamine (5-HT)
amyotrophic lateral sclerosis (ALS)
mouse model
serotonin deficiency
tryptophan hydroxylase (TPH)
videofluoroscopy
Journal
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
ISSN: 1097-6817
Titre abrégé: Otolaryngol Head Neck Surg
Pays: England
ID NLM: 8508176
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
pubmed:
1
5
2019
medline:
31
1
2020
entrez:
1
5
2019
Statut:
ppublish
Résumé
The intricate sensorimotor neural circuits that control swallowing are heavily reliant on serotonin (5-hydroxytryptamine [5-HT]); however, the impact of 5-HT deficiency on swallow function remains largely unexplored. We investigated this using mice deficient in tryptophan-hydroxylase-2 (TPH2), the enzyme catalyzing the rate-limiting step in 5-HT synthesis. Videofluoroscopy was utilized to characterize the swallowing function of TPH2 knockout (
Identifiants
pubmed: 31035861
doi: 10.1177/0194599819846109
pmc: PMC8341204
mid: NIHMS1728446
doi:
Substances chimiques
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
468-471Subventions
Organisme : NIDCD NIH HHS
ID : R21 DC016071
Pays : United States
Organisme : NIH HHS
ID : T32 OD011126
Pays : United States
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