Adverse and hormetic effects in rats exposed for 12 months to low dose mixture of 13 chemicals: RLRS part III.
Animals
Appetite Regulation
/ drug effects
Biomarkers
/ blood
Cholestasis
/ chemically induced
Complex Mixtures
/ toxicity
Cytokines
/ blood
Drinking
/ drug effects
Eating
/ drug effects
Female
Food Additives
/ toxicity
Hormesis
Inflammation Mediators
/ blood
Lymphocytes
/ drug effects
Male
Monocytes
/ drug effects
Pesticides
/ toxicity
Rats, Sprague-Dawley
Risk Assessment
Time Factors
Toxicity Tests, Chronic
Weight Gain
/ drug effects
Hormesis
Low dose exposure
Mixtures
Non-monotonic responses
Pesticides
Real life risk simulation (RLRS)
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
21
02
2019
revised:
27
03
2019
accepted:
05
04
2019
pubmed:
19
4
2019
medline:
29
5
2019
entrez:
19
4
2019
Statut:
ppublish
Résumé
The aim of the current study was to evaluate the effects of a mixture of thirteen common chemicals on rats, after a one-year exposure to doses around the acceptable daily intake (ADIs), using blood and urinary tests. The influence of low doses of the mixture on weight gain, water consumption, feed consumption and feed efficiency, biochemistry parameters, haematological parameters, blood lymphocytes subsets, serum inflammation profile and urine parameters was evaluated. Our mixture caused a moderate monotonic increase of the males' appetite and a non-monotonic increase of anabolism and a monotonic increase of appetite for the females. Regarding biochemical parameters, the exposure to the test mixture caused non-monotonic increases of AST and ALT, a decrease of PChE in males and plausibly a monotonic biliary obstruction in both sexes. Monocytes significantly increased in low dose groups of both sexes. A significant decrease of all the lymphocytes subclasses and an increased expression of TNF-α protein associated with an increased expression of IFN-γ protein observed in various groups. It became apparent that after twelve months of exposure very low doses of the tested mixture had both non-monotonic and monotonic harmful effects on different levels on rats.
Identifiants
pubmed: 30999039
pii: S0378-4274(19)30087-6
doi: 10.1016/j.toxlet.2019.04.005
pii:
doi:
Substances chimiques
Biomarkers
0
Complex Mixtures
0
Cytokines
0
Food Additives
0
Inflammation Mediators
0
Pesticides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-91Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.