[Determination of thresholds values for platelet serotonin and urinary 5-HIAA concentrations for the biological diagnosis of digestive neuroendocrine tumors].
Quelles valeurs de référence pour la concentration de la sérotonine plaquettaire et du 5-HIAA urinaire pour le diagnostic des tumeurs neuroendocrines digestives ?
Adult
Aged
Biomarkers
/ blood
Blood Chemical Analysis
/ methods
Blood Platelets
/ chemistry
Cohort Studies
Digestive System Neoplasms
/ blood
Female
Humans
Hydroxyindoleacetic Acid
/ analysis
Intestinal Neoplasms
/ blood
Male
Middle Aged
Neuroendocrine Tumors
/ blood
Pancreatic Neoplasms
/ blood
Reference Values
Retrospective Studies
Serotonin
/ analysis
Stomach Neoplasms
/ blood
Urinalysis
/ methods
digestives neuroendocrine tumors
platelet serotonin
threshold values
urinary 5-HIAA
Journal
Annales de biologie clinique
ISSN: 1950-6112
Titre abrégé: Ann Biol Clin (Paris)
Pays: France
ID NLM: 2984690R
Informations de publication
Date de publication:
01 04 2019
01 04 2019
Historique:
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
23
8
2019
Statut:
ppublish
Résumé
Platelet serotonin and its urinary metabolite 5-HIAA (5-hydroxyindolacetic acid) are the main biomarkers measured for the detection of neuroendocrine tumors (NET). We observe in our laboratory many false positives or false negatives for the 2 assays using threshold values given by the manufacturer. We aim to determine our own local threshold values for a better detection of gastrointestinal NETs. We studied patients with measurement of platelet serotonin and/or urinary 5-HIAA in University Hospital of Tours between January 2005 and June 2016. We established an « index » cohort with 75% of patients to determine local threshold value for the 2 parameters. A "validation" cohort constituted with 25% of remaining patients allowed us to compare the performances of manufacturer's values with local threshold values. Two hundred ninety patients were included, with 19 suffering from NETs. Local threshold value for platelet serotonin was determined at 5.13 amol/platelet, the one for urinary 5-HIAA at 3.60 μmol/mmol urinary creatinine. Platelet serotonin specificity was better with local threshold value for identical sensibility (0.75). Urinary 5-HIAA sensibility was improved with local threshold value (1 vs 0.667) for identical specificity (0.902). Using our local threshold value for platelet serotonin and urinary 5-HIAA improved diagnostic performances of these biochemical markers to detect NETs.
Identifiants
pubmed: 30998196
pii: abc.2019.1432
doi: 10.1684/abc.2019.1432
doi:
Substances chimiques
Biomarkers
0
Serotonin
333DO1RDJY
Hydroxyindoleacetic Acid
54-16-0
Types de publication
Journal Article
Validation Study
Langues
fre