Health benefits of subcutaneous zinc edetate and diphenyl diselenide in calves during the weaning period.
Age Factors
Animals
Antioxidants
/ analysis
Benzene Derivatives
/ administration & dosage
Body Weight
Cattle
/ physiology
Edetic Acid
/ administration & dosage
Immune System
/ drug effects
Injections, Subcutaneous
/ veterinary
Lipid Metabolism
/ drug effects
Malondialdehyde
/ blood
Muscles
/ metabolism
Organoselenium Compounds
/ administration & dosage
Proteins
/ metabolism
Reproducibility of Results
Selenium
/ administration & dosage
Time Factors
Weaning
Zinc
/ administration & dosage
Journal
Anais da Academia Brasileira de Ciencias
ISSN: 1678-2690
Titre abrégé: An Acad Bras Cienc
Pays: Brazil
ID NLM: 7503280
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
12
2017
accepted:
12
06
2018
entrez:
18
4
2019
pubmed:
18
4
2019
medline:
22
5
2019
Statut:
ppublish
Résumé
The aims of this study were to investigate whether treatments with zinc edetate (Zn) and diphenyl diselenide ((PhSe)2) enhance performance, immune responses, protein metabolism, and oxidant/antioxidant status in calf serum and muscle. Animals were divided into four groups (n=6 each): control (without supplementation), and groups supplemented on days 50 and 70 of life with (PhSe)2, Zn, and a combination of (PhSe)2 and Zn. Animals treated with (PhSe)2 gained more weight by experimental day 220 than did the control group, but there was no difference by the end of the experiment (day 300). The absolute number of leukocytes and lymphocytes increased in groups Zn and (PhSe)2+Zn on day 20 of experiment, but decreased on day 40 in groups (PhSe)2, and (PhSe)2+Zn. The number of monocytes decreased in all groups compared with control. One of the principal findings was that (PhSe)2+Zn together had beneficial effects on protein metabolism, represented by increases total protein and globulin levels, compared with the control group. The combination of (PhSe)2 and Zn led to low levels of TBARS and ROS in serum and muscle, and stimulated antioxidant enzyme activities. Thus, supplementation with (PhSe)2+Zn may be a compelling approach to augmenting the calf antioxidant system during weaning.
Identifiants
pubmed: 30994751
pii: S0001-37652019000100807
doi: 10.1590/0001-3765201920171042
pii:
doi:
Substances chimiques
Antioxidants
0
Benzene Derivatives
0
Organoselenium Compounds
0
Proteins
0
diphenyldiselenide
1666-13-3
Malondialdehyde
4Y8F71G49Q
Edetic Acid
9G34HU7RV0
Selenium
H6241UJ22B
Zinc
J41CSQ7QDS
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM