Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice.
Prevotella
alcoholic liver disease
ethanol-induced liver disease
microbiome
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
03 05 2020
03 05 2020
Historique:
pubmed:
16
4
2019
medline:
20
2
2021
entrez:
16
4
2019
Statut:
ppublish
Résumé
Alcohol-induced liver disease is closely related to translocation of bacterial products and bacteria from the intestine to the liver. However, it is not known whether bacterial translocation to the liver depends on certain intestinal microbiota changes that would predispose bacteria to translocate to the liver. In this study, we investigated the microbiota in the jejunum, ileum, cecum, feces and liver of mice subjected to chronic ethanol feeding using a Lieber DeCarli diet model of chronic ethanol feeding for 8 weeks. We demonstrate that chronic ethanol administration changes alpha diversity in the ileum and the liver and leads to compositional changes especially in the ileum. This is largely driven by an increase in gram-negative phyla - the source of endotoxins. Moreover, gram-negative
Identifiants
pubmed: 30982395
doi: 10.1080/19490976.2019.1595300
pmc: PMC7524386
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
265-275Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA020703
Pays : United States
Organisme : BLRD VA
ID : I01 BX004594
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA021856
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA024726
Pays : United States
Organisme : BLRD VA
ID : I01 BX002213
Pays : United States
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