Determination of mechanical and rheological properties of a cell-loaded peptide gel during ECM production.

Cells, Cultured Extracellular Matrix / metabolism Glycosaminoglycans / metabolism Humans Hydrogels Mesenchymal Stem Cells / metabolism Peptides Rheology Stress, Mechanical
Extracellular matrix GAG Glycosaminoglycans PuraMatrix Stress relaxation hMSc

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
30 May 2019
Historique:
received: 31 10 2018
revised: 09 04 2019
accepted: 09 04 2019
pubmed: 14 4 2019
medline: 29 8 2019
entrez: 14 4 2019
Statut: ppublish

Résumé

The development of an injectable biomaterial that supports cell survival and maintains or promotes nucleus pulposus (NP) phenotype could aid delivery of cells to degenerated NPs causing low back pain. Mesenchymal cells were loaded and grown in a synthetic peptide gel, PuraMatrix

Identifiants

DOI: 10.1016/j.ijpharm.2019.04.028 PMID: 30980887
pubmed: 30980887
pii: S0378-5173(19)30290-X
doi: 10.1016/j.ijpharm.2019.04.028
pii:
doi:

Substances chimiques

Glycosaminoglycans 0
Hydrogels 0
Peptides 0
RADA16-I 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

437-444

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

H Barreto-Henriksson (H)

Department of Clinical Immunology and Transfusion medicine, Sahlgrenska Hospital, Gothenburg, Sweden.

M Llorente (M)

Pharmaceutical Technology, Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden; SuMo BIOMATERIALS, VINN Excellence Center, Chalmers University of Technology, Gothenburg, Sweden.

A Larsson (A)

Pharmaceutical Technology, Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden; SuMo BIOMATERIALS, VINN Excellence Center, Chalmers University of Technology, Gothenburg, Sweden.

H Brisby (H)

Department of Orthopaedics, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden.

J Gold (J)

Biological Physics, Department of Physics, Chalmers University of Technology, Gothenburg, Sweden.

E Schuster (E)

Product Design and Perception, RISE Research Institutes of Sweden, Gothenburg, Sweden; SuMo BIOMATERIALS, VINN Excellence Center, Chalmers University of Technology, Gothenburg, Sweden.

A Ström (A)

Pharmaceutical Technology, Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden; SuMo BIOMATERIALS, VINN Excellence Center, Chalmers University of Technology, Gothenburg, Sweden. Electronic address: anna.strom@chalmers.se.

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Classifications MeSH

Recherchemedicale.com › Cellules › Cellules cultivées › Determination of mechanical and rheological...
Recherchemedicale.com › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › Determination of mechanical and rheological...
Recherchemedicale.com › Glucides › Polyosides › Glycosaminoglycanes › Determination of mechanical and rheological...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Determination of mechanical and rheological...
Recherchemedicale.com › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Determination of mechanical and rheological...
Recherchemedicale.com › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Determination of mechanical and rheological...
Recherchemedicale.com › Acides aminés, peptides et protéines › Peptides › Determination of mechanical and rheological...
Recherchemedicale.com › Disciplines des sciences naturelles › Physique › Rhéologie › Determination of mechanical and rheological...
Recherchemedicale.com › Phénomènes physiques › Phénomènes mécaniques › Contrainte mécanique › Determination of mechanical and rheological...