The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.
Adaptation, Physiological
Adaptive Immunity
Astronauts
Body Weight
Carotid Arteries
/ diagnostic imaging
Carotid Intima-Media Thickness
DNA Damage
DNA Methylation
Gastrointestinal Microbiome
Genomic Instability
Humans
Male
Space Flight
Telomere Homeostasis
Time Factors
United States
United States National Aeronautics and Space Administration
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
12 04 2019
12 04 2019
Historique:
received:
24
07
2018
accepted:
28
02
2019
entrez:
13
4
2019
pubmed:
13
4
2019
medline:
10
5
2019
Statut:
ppublish
Résumé
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight.
Identifiants
pubmed: 30975860
pii: 364/6436/eaau8650
doi: 10.1126/science.aau8650
pmc: PMC7580864
mid: NIHMS1618416
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : K01 AG035031
Pays : United States
Organisme : NHLBI NIH HHS
ID : K12 HL120001
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK035816
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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