Composite Lymphoma Containing Mantle Cell and Peripheral T-cell Lymphoma, Not Otherwise Specified: A Report of 2 Cases Treated With Up-front Autologous Stem Cell Transplantation.
Clone Cells
Composite Lymphoma
/ diagnosis
Female
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lymph Nodes
/ pathology
Lymphoma, Mantle-Cell
/ diagnosis
Lymphoma, T-Cell, Peripheral
/ diagnosis
Male
Middle Aged
Polymerase Chain Reaction
Remission Induction
Stem Cell Transplantation
Transplantation, Autologous
Journal
Applied immunohistochemistry & molecular morphology : AIMM
ISSN: 1533-4058
Titre abrégé: Appl Immunohistochem Mol Morphol
Pays: United States
ID NLM: 100888796
Informations de publication
Date de publication:
Historique:
pubmed:
12
4
2019
medline:
28
8
2021
entrez:
12
4
2019
Statut:
ppublish
Résumé
We report 2 cases of composite lymphoma comprising mantle cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, a rare association that has only been reported twice in the literature. In case 1, a 64-year-old woman presented with massive splenomegaly and lymphadenopathy. Immunohistochemical studies of the lymph node biopsy suggested the presence of 2 lymphomas, a predominant component of a peripheral T-cell lymphoma, not otherwise specified and an in situ mantle cell neoplasia. These suspicions were confirmed with polymerase chain reaction and fluorescence in situ hybridization studies. In case 2, a 45-year-old man presented with an enlarged right tonsil. Contrary to case 1, the biopsy suggested a predominant infiltration of a classical mantle cell lymphoma and an atypical proliferation of T cells. Biclonality was also confirmed with fluorescence in situ hybridization and molecular techniques. Both cases were treated with an up-front autologous stem cell transplantation after achieving first complete remission, and they remained free of disease for a long period of time.
Identifiants
pubmed: 30973352
doi: 10.1097/PAI.0000000000000769
pii: 00129039-202011000-00013
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e94-e98Références
Kim H, Hendrickson MR, Dorfman RF. Composite lymphoma. Cancer. 1977;40:959–976.
Wang E, Papavassiliou P, Wang AR, et al. Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases. Hum Pathol. 2014;45:768–784.
Katsushima H, Nakajima S, Takagawa M, et al. A composite lymphoma consisting of a mantle cell lymphoma and a peripheral T-cell lymphoma. A rare case with literature review. AJSP: Reviews & Reports. 2018;23:255–261.
Goyal G, Nguyen AH, Kendric K, et al. Composite lymphoma with diffuse large B-cell lymphoma and classical Hodgkin lymphoma components: a case report and review of the literature. Pathol Res Pract. 2016;212:1179–1190.
Tanaka J, Su P, Luedke C, et al. Composite lymphoma of follicular B-cell and peripheral T-cell types with distinct zone distribution in a 75-year-old male patient: a case study. Hum Pathol. 2018;76:110–116.
Jonjić N, Seili Bekafigo I, Fučkar Čupić D, et al. Rapid fatal acute peripheral T-cell lymphoma associated with IgG plasma cell leukemia and IgA hypergammaglobulinemia. Appl Immunohistochem Mol Morphol AIMM. 2016;24:e89–e93.
Carvajal-Cuenca A, Sua LF, Silva NM, et al. In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior. Haematologica. 2012;97:270–278.
Richard P, Vassallo J, Valmary S, et al. “In situ-like” mantle cell lymphoma: a report of two cases. J Clin Pathol. 2006;59:995–996.
Marí-Jimenez P, Martínez-Losada C, Centeno-Haro M, et al. A rare composite lymphoma: follicular and in situ mantle cell. Ann Hematol. 2016;95:1351–1352.
Beà S, Valdés-Mas R, Navarro A, et al. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. Proc Natl Acad Sci U S A. 2013;110:18250–18255.
Küppers R, Dührsen U, Hansmann M-L. Pathogenesis, diagnosis, and treatment of composite lymphomas. Lancet Oncol. 2014;15:e435–e446.
Dreyling M, Campo E, Hermine O, et al. Newly diagnosed and relapsed mantle cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol. 2017;28(suppl 4):iv62–iv71.
d’Amore F, Gaulard P, Trümper L, et al. Peripheral T-cell lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol. 2015;26(suppl 5):v108–v115.