Sleep deprivation exacerbates concussive head injury induced brain pathology: Neuroprotective effects of nanowired delivery of cerebrolysin with α-melanocyte-stimulating hormone.
Blood-brain barrier
Brain edema
Brain pathology
Cerebrolysin
Concussive head injury
Sleep deprivation
α-Melanocyte stimulating hormone
Journal
Progress in brain research
ISSN: 1875-7855
Titre abrégé: Prog Brain Res
Pays: Netherlands
ID NLM: 0376441
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
6
6
2019
Statut:
ppublish
Résumé
Sleep deprivation (SD) is very common in military personnel resulting in mental anomalies and interfering with decision-making capabilities. Moreover during combat operation, these sleep-deprived soldiers often receive blunt head trauma casing concussive head injury (CHI). Recent observations clearly suggest that SD alone induces brain pathology and additional CHI further exacerbates brain damage. Thus, the need of the hour is to explore possible effective therapeutic measures to induce neuroprotection to enhance quality of life of these military personnel. This review deals with novel aspects of treatment using nanotechnology to induce superior neuroprotection following CHI in SD based on our own investigation in the light of recent literature in the field.
Identifiants
pubmed: 30961865
pii: S0079-6123(19)30032-9
doi: 10.1016/bs.pbr.2019.03.002
pii:
doi:
Substances chimiques
Amino Acids
0
Neuroprotective Agents
0
cerebrolysin
37KZM6S21G
alpha-MSH
581-05-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-55Informations de copyright
© 2019 Elsevier B.V. All rights reserved.