Cyclodextrin-Polypyrrole Coatings of Scaffolds for Tissue Engineering.
cyclodextrin
functionalisation
microfibres
polycaprolactone
polypyrrole
pyrrole
scaffold
tissue engineering
Journal
Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357
Informations de publication
Date de publication:
11 Mar 2019
11 Mar 2019
Historique:
received:
24
01
2019
revised:
01
03
2019
accepted:
06
03
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
10
4
2019
Statut:
epublish
Résumé
Polypyrrole is one of the most investigated conductive polymers used for tissue engineering applications because of its advantageous properties and the ability to promote different cell types' adhesion and proliferation. Together with β-cyclodextrin, which is capable of accommodating helpful biomolecules in its cavity, it would make a perfect couple for use as a scaffold for tissue engineering. Such scaffolds were prepared by the polymerisation of 6-(pyrrol-3-yl)hexanoic acid on polycaprolactone microfibres with subsequent attachment of β-cyclodextrin on the polypyrrole layer. The materials were deeply characterised by several physical and spectroscopic techniques. Testing of the cyclodextrin enriched composite scaffold revealed its better performance in in vitro experiments compared with pristine polycaprolactone or polypyrrole covered polycaprolactone scaffolds.
Identifiants
pubmed: 30960443
pii: polym11030459
doi: 10.3390/polym11030459
pmc: PMC6473528
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerstvo Školství, Mládeže a Tělovýchovy
ID : CZ.02.1.01/0.0/0.0/16_019/0000843
Organisme : Grantová Agentura České Republiky
ID : 16-02316Y
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