Long noncoding RNA STCAT16 suppresses cell growth and its expression predicts prognosis in patients with gastric cancer.
Adult
Aged
Aged, 80 and over
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic
/ genetics
Disease Progression
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Humans
Male
Middle Aged
Neoplasm Staging
Prognosis
RNA, Long Noncoding
/ genetics
Stomach Neoplasms
/ diagnosis
Journal
Molecular medicine reports
ISSN: 1791-3004
Titre abrégé: Mol Med Rep
Pays: Greece
ID NLM: 101475259
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
11
07
2018
accepted:
19
03
2019
pubmed:
9
4
2019
medline:
27
8
2019
entrez:
9
4
2019
Statut:
ppublish
Résumé
Gastric cancer (GC) is a leading cause of cancer‑associated mortality worldwide. Previous studies demonstrated that long noncoding RNAs (lncRNAs) may be dysregulated in GC and may serve important roles in cancer progression. The present study aimed to investigate the role of the novel lncRNA stomach cancer‑associated transcript 16 (STCAT16; Assembly Gene ID G038291) in the development and progression of GC. The present data suggested that the expression level of STCAT16 was decreased in GC tissues. The expression level of STCAT16 was identified to be associated with lymph node and tumour node metastasis stages. Furthermore, the expression level of STCAT16 was identified to be significantly associated with poor survival and prognosis. Knockdown of STCAT16 promoted proliferation, colony formation, migration and invasion of BGC‑823 cells. In contrast, these features were suppressed in AGS cells following overexpression of STCAT16. In vivo, tumour growth was significantly decreased following STCAT16 overexpression. Collectively, the present data suggested that the lncRNA STCAT16 may act as a tumour suppressor and may inhibit GC tumour cell growth and migration. Additionally, the decreased expression level of STCAT16 was identified to be associated with poor prognosis in patients with GC.
Identifiants
pubmed: 30957180
doi: 10.3892/mmr.2019.10128
pmc: PMC6522818
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Pagination
4613-4622Références
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