Distinct and opposite profiles of connectivity during self-reference task and rest in youth at clinical high risk for psychosis.
prodrome
psychosis
resting-state
self-reference
self-reflection
theory of mind
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
received:
25
01
2019
revised:
24
03
2019
accepted:
26
03
2019
pubmed:
4
4
2019
medline:
1
4
2020
entrez:
4
4
2019
Statut:
ppublish
Résumé
Self-reference is impaired in psychotic disorders such as schizophrenia, associated with disability, and closely related to characteristic patterns of aberrant brain connectivity. However, at present, it is unclear whether self-reference is impacted in pathogenesis of the disorder. Alterations in connectivity during a self-reference task or resting-state in the psychosis risk (i.e., prodromal) period may yield important clues for biomarker development, as well as for novel treatment targets. This study examined a task-based and resting-state functional magnetic resonance imaging in individuals at clinical high risk (CHR) for psychosis (n = 22) and healthy control unaffected peers (n = 20). The self-reference task comprised three task conditions where subjects were asked if an adjective was relevant to themselves (self), a designated other individual (other), or to evaluate the word's spelling (letter). Connectivity analyses examined medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC), regions commonly found in conjunction analyses of self-reference, during both the self-reference task and rest. In task connectivity analyses, CHR individuals exhibited decreased mPFC-PCC connectivity when compared to controls. In resting-state analyses, CHR participants showed greater mPFC-PCC connectivity. Taken together, results suggest that psychosis-like alterations in mPFC-PCC connectivity is present prior to psychosis onset across both task and rest.
Identifiants
pubmed: 30941844
doi: 10.1002/hbm.24595
pmc: PMC6592773
mid: NIHMS1026342
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3254-3264Subventions
Organisme : NIH HHS
ID : MH112545
Pays : United States
Organisme : NIMH NIH HHS
ID : R33 MH103231
Pays : United States
Organisme : NIH HHS
ID : T32HD040127
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH110374
Pays : United States
Organisme : NIH HHS
ID : R21MH110374
Pays : United States
Organisme : NIH HHS
ID : MH094650
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH103231
Pays : United States
Organisme : NIH HHS
ID : R01s. MH094650
Pays : United States
Organisme : NIH HHS
ID : MH112545-01
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD040127
Pays : United States
Organisme : NIH HHS
ID : R21/R33MH103231
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112545
Pays : United States
Organisme : NIH HHS
ID : MH103231
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094650
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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