Genes Located on 18q23 Are Epigenetic Markers and Have Prognostic Significance for Patients with Head and Neck Cancer.

18q23 CpG island LOH disease-free survival head and neck cancer promoter methylation quantitative methylation-specific PCR

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
21 Mar 2019
Historique:
received: 10 02 2019
revised: 28 02 2019
accepted: 18 03 2019
entrez: 24 3 2019
pubmed: 25 3 2019
medline: 25 3 2019
Statut: epublish

Résumé

Loss of heterozygosity (LOH) on chromosome 18q23 is associated with significantly decreased survival in head and neck cancer. In agreement with such tumor suppressive roles, the loss of function of genes located in this region can be achieved through LOH and promotor hypermethylation. In this study, the methylation status of promoters of 18q23 genes in 243 head and neck cancer patients was assessed by quantitative methylation-specific PCR. Promoter methylation was then compared to various clinical characteristics and patient survival.

Identifiants

DOI: 10.3390/cancers11030401 PMID: 30901947 PMC: PMC6468360
pubmed: 30901947
pii: cancers11030401
doi: 10.3390/cancers11030401
pmc: PMC6468360
pii:
doi:

Types de publication

Journal Article

Langues

eng

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Kiyoshi Misawa (K)

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. kiyoshim@hama-med.ac.jp.

Takeharu Kanazawa (T)

Department of Otolaryngology, Tokyo Voice Center, International University of Health and Welfare, Tokyo 107-0052, Japan. mayuinannarbor@yahoo.co.jp.

Daiki Mochizuki (D)

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. daiki_m525@yahoo.co.jp.

Atsushi Imai (A)

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. imaimimi@yahoo.co.jp.

Masato Mima (M)

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. tendoon@gmail.com.

Satoshi Yamada (S)

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. veridique.star@gmail.com.

Kotaro Morita (K)

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. drb94amm1307@yahoo.co.jp.

Yuki Misawa (Y)

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. mswyuki@abox3.so-net.ne.jp.

Kazuya Shinmura (K)

Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. kzshinmu@hama-med.ac.jp.

Hiroyuki Mineta (H)

Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan. mineta@hama-med.ac.jp.

Classifications MeSH