Diurnal variations in flow density measured using optical coherence tomography angiography and the impact of heart rate, mean arterial pressure and intraocular pressure on flow density in primary open-angle glaucoma patients.
Arterial Pressure
/ physiology
Capillaries
/ diagnostic imaging
Circadian Rhythm
/ physiology
Cross-Sectional Studies
Female
Fluorescein Angiography
/ methods
Fundus Oculi
Glaucoma, Open-Angle
/ diagnosis
Heart Rate
/ physiology
Humans
Intraocular Pressure
/ physiology
Macula Lutea
/ blood supply
Male
Middle Aged
Optic Disk
/ blood supply
Retinal Vessels
/ diagnostic imaging
Retrospective Studies
Tomography, Optical Coherence
/ methods
Visual Fields
blood pressure
diurnal variations
flow density
heart rate
intraocular pressure
open-angle glaucoma
optical coherence tomography angiography
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
13
07
2018
accepted:
21
02
2019
pubmed:
23
3
2019
medline:
4
9
2019
entrez:
23
3
2019
Statut:
ppublish
Résumé
To determine the diurnal variations in peripapillary and macular flow density (FD), as measured using optical coherence tomography angiography (OCTA) and to elaborate on the relationship between diurnal FD, circulatory parameters and intraocular pressure (IOP) variations in primary open-angle glaucoma (POAG). Forty eyes of 40 POAG patients were drawn into this cross-sectional study. The retinal microvasculature of the macula (superficial and deep layers) and optic nerve [radial peripapillary capillary (RPC)] was examined by OCTA (AngioVue While superficial macular FD and RPC FD revealed not to be affected by diurnal variations (p = 0.492, p = 0.319), FD in the deep layer of the macula increased throughout the day (p < 0.001). Superficial macular FD was influenced significantly by mean arterial pressure (MAP) (p = 0.006) and heart rate (HR) (p = 0.033), whereas FD in the RPC layer was significantly affected by HR (p = 0.010). No statistically significant effect of IOP fluctuations on FD was observed. This study shows diurnal fluctuations of deep macular FD measured by OCTA and outlines the relationship between FD and hemodynamic parameters (MAP/HR) in POAG patients.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e844-e849Informations de copyright
© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.