Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study.
Aged
Bone Density
Female
Gene Frequency
/ genetics
Genetic Association Studies
Humans
Middle Aged
Osteoporosis, Postmenopausal
/ genetics
Osteoporotic Fractures
/ genetics
Pilot Projects
Polymorphism, Genetic
/ genetics
Retrospective Studies
Spinal Fractures
/ genetics
Turkey
Vitamin K Epoxide Reductases
/ genetics
Journal
Clinics (Sao Paulo, Brazil)
ISSN: 1980-5322
Titre abrégé: Clinics (Sao Paulo)
Pays: United States
ID NLM: 101244734
Informations de publication
Date de publication:
14 03 2019
14 03 2019
Historique:
received:
10
04
2018
accepted:
28
11
2018
entrez:
21
3
2019
pubmed:
21
3
2019
medline:
6
6
2019
Statut:
epublish
Résumé
In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.
Identifiants
pubmed: 30892416
pii: S1807-5932(22)00646-9
doi: 10.6061/clinics/2019/e739
pmc: PMC6399659
pii:
doi:
Substances chimiques
VKORC1 protein, human
EC 1.17.4.4
Vitamin K Epoxide Reductases
EC 1.17.4.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e739Références
Vitam Horm. 2008;78:23-33
pubmed: 18374188
Arch Intern Med. 2006 Jun 26;166(12):1256-61
pubmed: 16801507
Postgrad Med J. 2007 Aug;83(982):509-17
pubmed: 17675543
Can Fam Physician. 2004 Jul;50:993-7
pubmed: 15317231
Am J Obstet Gynecol. 2006 Feb;194(2 Suppl):S3-11
pubmed: 16448873
Pharmacogenet Genomics. 2010 Oct;20(10):642-4
pubmed: 19940803
Health Technol Assess. 2009 Sep;13(45):iii-xi, 1-134
pubmed: 19818211
Osteoporos Int. 2011 Apr;22(4):1219-25
pubmed: 20532479
Altern Med Rev. 2005 Mar;10(1):24-35
pubmed: 15771560
Endocr Rev. 2010 Oct;31(5):629-62
pubmed: 20431112
J Clin Densitom. 2013 Oct-Dec;16(4):409-13
pubmed: 24090644
Indian J Med Res. 2013 Apr;137(4):734-41
pubmed: 23703341
Nucleic Acids Res. 1988 Feb 11;16(3):1215
pubmed: 3344216
J Nutr Gerontol Geriatr. 2014;33(1):10-22
pubmed: 24597993
J Bone Miner Res. 1996 Jul;11(7):984-96
pubmed: 8797120
Osteoporos Int. 1990 Oct;1(1):56-60
pubmed: 2133642
PLoS One. 2010 Dec 13;5(12):e15088
pubmed: 21179439
Proc Natl Acad Sci U S A. 1975 Oct;72(10):3925-9
pubmed: 1060074
Osteoporos Int. 2012 Nov;23(11):2681-92
pubmed: 22398856
Am J Manag Care. 2011 May;17 Suppl 6:S164-9
pubmed: 21761955
Curr Opin Rheumatol. 2005 Jul;17(4):456-61
pubmed: 15956843
Best Pract Res Clin Endocrinol Metab. 2008 Oct;22(5):723-35
pubmed: 19028354
Biochem Biophys Res Commun. 2014 Sep 19;452(2):287-93
pubmed: 25139232
Am J Clin Nutr. 1999 Jan;69(1):74-9
pubmed: 9925126
Pharmacogenomics. 2009 Jun;10(6):1025-32
pubmed: 19530970
Transl Res. 2010 Jul;156(1):37-44
pubmed: 20621035
Clinics (Sao Paulo). 2012 Nov;67(11):1299-302
pubmed: 23184207