T Cells Specific for an Unconventional Natural Antigen Fail to Recognize Leukemic Cells.
Journal
Cancer immunology research
ISSN: 2326-6074
Titre abrégé: Cancer Immunol Res
Pays: United States
ID NLM: 101614637
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
05
03
2018
revised:
21
12
2018
accepted:
14
03
2019
pubmed:
21
3
2019
medline:
23
7
2020
entrez:
21
3
2019
Statut:
ppublish
Résumé
MHC-bound peptides from aberrant proteins may be a specific immunotherapeutic target on cancer cells. Because of difficulties in identifying such antigens, viral or model antigens have so far been used to study their biological relevance. We here identify a naturally existing human T-cell epitope derived from a truncated protein. The antigenic peptide is derived from the gene
Identifiants
pubmed: 30890530
pii: 2326-6066.CIR-18-0137
doi: 10.1158/2326-6066.CIR-18-0137
doi:
Substances chimiques
Epitopes, T-Lymphocyte
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-804Informations de copyright
©2019 American Association for Cancer Research.