Ammonium tetrathiomolybdate treatment of copper-associated hepatopathy in dogs.
Labrador Retrievers
chelation
copper toxicosis
hepatitis
molybdenum
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
11
09
2018
accepted:
22
02
2019
pubmed:
19
3
2019
medline:
29
10
2019
entrez:
19
3
2019
Statut:
ppublish
Résumé
Copper-associated hepatopathy (CAH) is a common cause of liver disease in dogs. Although d-penicillamine can be an effective treatment, some dogs fail treatment or develop adverse effects. Ammonium tetrathiomolybdate (TTM) has been used to treat pathologic copper accumulation in other species, but its therapeutic potential for CAH is unknown. To investigate short-term safety and efficacy of TTM for treatment of CAH. Ten dogs with CAH. Prospective study. All dogs were treated with TTM PO for 6 weeks, and hepatic biopsies were performed after the treatment course. Dog experiencing initial decreases in hepatic copper concentrations ([Cu] Eight of 10 dogs had decreases in [Cu] Results suggest that TTM can effectively decrease [Cu]
Sections du résumé
BACKGROUND
BACKGROUND
Copper-associated hepatopathy (CAH) is a common cause of liver disease in dogs. Although d-penicillamine can be an effective treatment, some dogs fail treatment or develop adverse effects. Ammonium tetrathiomolybdate (TTM) has been used to treat pathologic copper accumulation in other species, but its therapeutic potential for CAH is unknown.
OBJECTIVES
OBJECTIVE
To investigate short-term safety and efficacy of TTM for treatment of CAH.
ANIMALS
METHODS
Ten dogs with CAH.
METHODS
METHODS
Prospective study. All dogs were treated with TTM PO for 6 weeks, and hepatic biopsies were performed after the treatment course. Dog experiencing initial decreases in hepatic copper concentrations ([Cu]
RESULTS
RESULTS
Eight of 10 dogs had decreases in [Cu]
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Results suggest that TTM can effectively decrease [Cu]
Identifiants
pubmed: 30883912
doi: 10.1111/jvim.15474
pmc: PMC6524386
doi:
Substances chimiques
Chelating Agents
0
Copper
789U1901C5
Molybdenum
81AH48963U
tetrathiomolybdate
91U3TGV99T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1336-1343Informations de copyright
© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
Références
Transl Res. 2009 Aug;154(2):70-7
pubmed: 19595438
Clin Cancer Res. 2018 Sep 1;24(17):4271-4281
pubmed: 30065097
J Hepatol. 2004 Mar;40(3):409-16
pubmed: 15123354
Metallomics. 2009;1(3):199-206
pubmed: 21305118
Vet Clin North Am Small Anim Pract. 2016 May;46(3):453-80, v-vi
pubmed: 26851975
J Vet Intern Med. 2015 May-Jun;29(3):822-7
pubmed: 25776942
Vet Clin North Am Small Anim Pract. 2009 May;39(3):489-511
pubmed: 19524791
Integr Cancer Ther. 2002 Dec;1(4):327-37
pubmed: 14664727
Vet Rec. 1988 Jul 9;123(2):51-3
pubmed: 3413942
J Am Vet Med Assoc. 2013 Feb 1;242(3):372-80
pubmed: 23327181
J Vet Intern Med. 2006 Jul-Aug;20(4):856-61
pubmed: 16955809
J Vet Intern Med. 2013 Sep-Oct;27(5):1071-6
pubmed: 23875792
Am J Vet Res. 2015 May;76(5):445-53
pubmed: 25909377
Am J Clin Pathol. 2000 Jan;113(1):40-55
pubmed: 10631857
J Alzheimers Dis. 2010;21(3):903-14
pubmed: 20693639
J Comp Pathol. 2004 Jan;130(1):21-31
pubmed: 14693121
Hepatology. 1996 Aug;24(2):289-93
pubmed: 8690394
Lancet. 2007 Feb 3;369(9559):397-408
pubmed: 17276780
Hum Mol Genet. 2002 Jan 15;11(2):165-73
pubmed: 11809725
J Vet Intern Med. 2013 May-Jun;27(3):491-9
pubmed: 23527903
Lancet Gastroenterol Hepatol. 2017 Dec;2(12):869-876
pubmed: 28988934
Vet Pathol. 1986 Mar;23(2):148-54
pubmed: 3962081
J Vet Intern Med. 2012 Nov-Dec;26(6):1274-80
pubmed: 22998127
J Vet Intern Med. 2009 Sep-Oct;23(5):957-63
pubmed: 19627473
Vet J. 2013 Jun;196(3):522-7
pubmed: 23375251
Am J Vet Res. 2013 Dec;74(12):1474-80
pubmed: 24274883
J Am Vet Med Assoc. 1992 Aug 15;201(4):564-8
pubmed: 1517130
Am J Med. 1956 Oct;21(4):487-95
pubmed: 13362281
Vet Pathol. 2009 May;46(3):484-90
pubmed: 19176511
Arch Neurol. 2006 Apr;63(4):521-7
pubmed: 16606763
Vet Clin North Am Small Anim Pract. 2017 May;47(3):631-644
pubmed: 28063745
Can Vet J. 2014 Jun;55(6):573-6
pubmed: 24891642
J Vet Intern Med. 2008 Jul-Aug;22(4):1038-42
pubmed: 18647161
Vet Clin North Am Small Anim Pract. 1995 Mar;25(2):399-417
pubmed: 7785171
J Vet Intern Med. 2019 May;33(3):1336-1343
pubmed: 30883912
Dis Model Mech. 2016 Jan;9(1):25-38
pubmed: 26747866
Arch Neurol. 1991 Jan;48(1):42-7
pubmed: 1986725
J Vet Intern Med. 2018 Nov;32(6):1943-1950
pubmed: 30294943
J Vet Intern Med. 2018 May;32(3):1009-1018
pubmed: 29485210
Br J Nutr. 1998 Apr;79(4):329-31
pubmed: 9624223
Vet Hum Toxicol. 1989 Dec;31(6):535-7
pubmed: 2617835
J Vet Intern Med. 2002 Nov-Dec;16(6):665-8
pubmed: 12465762
J Vet Intern Med. 2004 Sep-Oct;18(5):647-50
pubmed: 15515579