Prevalence of Arthritis and Rheumatoid Arthritis in Coal Mining Counties of the United States.
Age Factors
Aged
Appalachian Region
/ epidemiology
Arthritis
/ epidemiology
Arthritis, Rheumatoid
/ epidemiology
Coal Mining
Humans
Male
Middle Aged
Occupational Diseases
/ epidemiology
Occupational Exposure
/ adverse effects
Odds Ratio
Prevalence
Risk Assessment
Silicon Dioxide
/ adverse effects
Surveys and Questionnaires
United States
/ epidemiology
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
13
10
2018
accepted:
05
03
2019
pubmed:
16
3
2019
medline:
18
3
2020
entrez:
16
3
2019
Statut:
ppublish
Résumé
Exposure to inhaled mineral dust, in particular silica, is associated with increased odds of rheumatoid arthritis (RA) and other autoimmune diseases. We studied the association of RA with work-related coal and silica exposure in the Appalachian region of the US. We carried out a random-digit dialed telephone survey in selected counties in Appalachia that had elevated coal workers' pneumoconiosis mortality. Our study cohort included men ages ≥50 with any employment history, and we assessed exposure to coal mining employment, other work-related dust, and ergonomic factors. We ascertained self-reported physician diagnosis of any arthritis and of RA with glucocorticoid treatment. We used multivariable logistic regression analysis to estimate the odds ratios (ORs) and associated population attributable fraction (PAF) estimates. Among the 973 men who met study entry criteria (mean ± SD ages 66 ± 10 years; 54% ever smokers), 266 (27%) reported coal mining work and 189 (19%) reported other work-related silica exposure. There were 517 men (53%), who reported any arthritis and 112 (12%) whose disease met the study definition of RA. Adjusting for covariates, coal mining was associated with elevated odds of RA (OR 3.6 [95% confidence interval (95% CI) 2.1-6.2]), which accounted for a PAF of 33% (95% CI 26-40%) of the men studied. For any arthritis, the coal mining-associated OR was 2.3 (95% CI 1.6-3.2), with an associated PAF of 20% (95% CI 14-25%). In this population of older males living in a coal mining region, we estimated that 20% of arthritis and 33% of RA may be attributable to coal mining work.
Identifiants
pubmed: 30875457
doi: 10.1002/acr.23874
pmc: PMC6717008
mid: NIHMS1016498
doi:
Substances chimiques
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1209-1215Subventions
Organisme : NIAMS NIH HHS
ID : K23 AR063770
Pays : United States
Informations de copyright
© 2019, American College of Rheumatology.
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