PDGF-B Is Required for Development of the Glymphatic System.
aquaporin 4
astrocytes
cerebrospinal fluid
glymphatic system
platelet-derived growth factor B
postnatal development
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
12 03 2019
12 03 2019
Historique:
received:
03
07
2018
revised:
07
01
2019
accepted:
13
02
2019
entrez:
14
3
2019
pubmed:
14
3
2019
medline:
16
4
2020
Statut:
ppublish
Résumé
The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb
Identifiants
pubmed: 30865886
pii: S2211-1247(19)30229-3
doi: 10.1016/j.celrep.2019.02.050
pmc: PMC6447074
mid: NIHMS1523852
pii:
doi:
Substances chimiques
Aqp4 protein, mouse
0
Aquaporin 4
0
Lymphokines
0
Pdgfd protein, mouse
0
Platelet-Derived Growth Factor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2955-2969.e3Subventions
Organisme : NIA NIH HHS
ID : R01 AG048769
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG053991
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057575
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS110049
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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