Transfer of Sequence Information and Replication of Diimine Duplexes.
Journal
The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R
Informations de publication
Date de publication:
05 04 2019
05 04 2019
Historique:
pubmed:
12
3
2019
medline:
3
6
2020
entrez:
12
3
2019
Statut:
ppublish
Résumé
The ability of the biopolymers RNA and DNA to store and transfer information is essential to life. Herein, we demonstrate template-directed replication in a set of dimer duplexes that use reversible covalent bonds to form base-pairing interactions. Binary sequence information was encoded as a sequence of aniline and benzaldehyde subunits linked together by a diethynyl benzene backbone. These dimers formed sequence-specific, imine-linked duplexes, which could be separated and used as templates for the synthesis of daughter duplexes with identical sequences.
Identifiants
pubmed: 30855962
doi: 10.1021/acs.joc.9b00095
pmc: PMC7547894
doi:
Substances chimiques
Aniline Compounds
0
Benzaldehydes
0
Imines
0
RNA
63231-63-0
DNA
9007-49-2
aniline
SIR7XX2F1K
benzaldehyde
TA269SD04T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3754-3761Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
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