The Human Ventromedial Prefrontal Cortex: Sulcal Morphology and Its Influence on Functional Organization.
Default Mode Network
function
morphology
sulcus
vmPFC
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
08 05 2019
08 05 2019
Historique:
received:
11
08
2018
revised:
21
11
2018
accepted:
09
01
2019
pubmed:
6
3
2019
medline:
12
6
2020
entrez:
6
3
2019
Statut:
ppublish
Résumé
The ventromedial prefrontal cortex (vmPFC), which comprises several distinct cytoarchitectonic areas, is a key brain region supporting decision-making processes, and it has been shown to be one of the main hubs of the Default Mode Network, a network classically activated during resting state. We here examined the interindividual variability in the vmPFC sulcal morphology in 57 humans (37 females) and demonstrated that the presence/absence of the inferior rostral sulcus and the subgenual intralimbic sulcus influences significantly the sulcal organization of this region. Furthermore, the sulcal organization influences the location of the vmPFC peak of the Default Mode Network, demonstrating that the location of functional activity can be affected by local sulcal patterns. These results are critical for the investigation of the function of the vmPFC and show that taking into account the sulcal variability might be essential to guide the interpretation of neuroimaging studies.
Identifiants
pubmed: 30833514
pii: JNEUROSCI.2060-18.2019
doi: 10.1523/JNEUROSCI.2060-18.2019
pmc: PMC6510347
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3627-3639Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Organisme : Wellcome Trust
ID : 203139/Z/16/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 105651/Z/14/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Lopez-Persem et al.
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